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  Neuroimaging technological advancements for targeting in functional neurosurgery

Boutet, A., Gramer, R., Steele, C., Elias, G. J. B., Germann, J., Maciel, R., et al. (2019). Neuroimaging technological advancements for targeting in functional neurosurgery. Current Neurology and Neuroscience Reports, 19: 42. doi:10.1007/s11910-019-0961-8.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-C7E6-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-C7E7-8
Genre: Journal Article

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 Creators:
Boutet, Alexandre1, 2, Author
Gramer, Robert2, Author
Steele, Christopher3, 4, Author              
Elias, Gavin J. B.2, Author
Germann, Jürgen2, Author
Maciel, Ricardo2, 5, Author
Kucharczyk, Walter1, 2, Author
Zrinzo, Ludvic6, Author
Lozano, Andres M.2, Author
Fasano, Alfonso2, 7, 8, Author
Affiliations:
1Joint Department of Medical Imaging, University of Toronto, ON, Canada, ou_persistent22              
2University Health Network, University of Toronto, ON, Canada, ou_persistent22              
3Department of Psychology, Concordia University, Montréal, QC, Canada, ou_persistent22              
4Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
5Morton and Gloria Shulman Movement Disorders Clinic, University Health Network, University of Toronto, ON, Canada, ou_persistent22              
6Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, United Kingdom, ou_persistent22              
7Krembil Brain Institute, University Health Network, University of Toronto, ON, Canada, ou_persistent22              
8Center for Advancing Neurotechnological Innovation to Application (CRANIA), Toronto, ON, Canada, ou_persistent22              

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Free keywords: Deep brain stimulation; Functional neurosurgery; MRI; Neuroimaging
 Abstract: Purpose of Review Ablations and particularly deep brain stimulation (DBS) of a variety of CNS targets are established therapeutic tools for movement disorders. Accurate targeting of the intended structure is crucial for optimal clinical outcomes. However, most targets used in functional neurosurgery are sub-optimally visualized on routine MRI. This article reviews recent neuroimaging advancements for targeting in movement disorders. Recent Findings Dedicated MRI sequences can often visualize to some degree anatomical structures commonly targeted during DBS surgery, including at 1.5-T field strengths. Due to recent technological advancements, MR images using ultra-high magnetic field strengths and new acquisition parameters allow for markedly improved visualization of common movement disorder targets. In addition, novel neuroimaging techniques have enabled group-level analysis of DBS patients and delineation of areas associated with clinical benefits. These areas might diverge from the conventionally targeted nuclei and may instead correspond to white matter tracts or hubs of functional networks. Summary Neuroimaging advancements have enabled improved direct visualization-based targeting as well as optimization and adjustment of conventionally targeted structures.

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Language(s): eng - English
 Dates: 2019-07
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1007/s11910-019-0961-8
PMID: 31144155
 Degree: -

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Title: Current Neurology and Neuroscience Reports
Source Genre: Journal
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Publ. Info: Philadelphia, PA, USA : Current Science
Pages: - Volume / Issue: 19 Sequence Number: 42 Start / End Page: - Identifier: ISSN: 1534-6293
CoNE: https://pure.mpg.de/cone/journals/resource/1534-6293