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  Genetic diversity of HLA system in three populations from Guanajuato, Mexico: Guanajuato City, León and rural Guanajuato

Pantoja-Torres, J. A., Barquera, R., Ballesteros-Romero, M., Bravo-Acevedo, A., Arrieta-Bolaños, E., Montiel-Hernández, G. D., et al. (2019). Genetic diversity of HLA system in three populations from Guanajuato, Mexico: Guanajuato City, León and rural Guanajuato. Human Immunology. doi:10.1016/j.humimm.2019.06.002.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-CA4E-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-CA4F-2
Genre: Journal Article

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 Creators:
Pantoja-Torres, Jorge Arturo, Author
Barquera, Rodrigo1, Author              
Ballesteros-Romero, Mónica, Author
Bravo-Acevedo, Alicia, Author
Arrieta-Bolaños, Esteban, Author
Montiel-Hernández, Gustavo Daniel, Author
Clayton, Stephen, Author
Rodríguez-Rodríguez, Lidia Iris, Author
Hernández-Zaragoza, Diana Iraíz, Author
Goné-Vázquez, Isis, Author
Escobedo-Ruíz, Araceli, Author
García-Arias, Víctor Eduardo, Author
Arellano-Prado, Francia Paulina, Author
Rodríguez-López, Marla Estefanía, Author
de Sánchez-Fernández, María Guadalupe Jesús, Author
Sandoval-Sandoval, Mario J., Author
Gómez-Navarro, Benjamín, Author
Zúñiga, Joaquín, Author
Yunis, Edmond J., Author
Bekker-Méndez, Carolina, Author
Granados, Julio, Author more..
Affiliations:
1Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2074310              

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Free keywords: HLA, Immunogenetics, Population genetics, Guanajuato, Admixture
 Abstract: We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 262 Mexicans from the state of Guanajuato living in the cities of Guanajuato (N = 78), León (N = 22) and rural communities (N = 162), to obtain information regarding allelic and haplotypic frequencies. We find that the most frequent haplotypes found in the state of Guanajuato include 12 Native American and three European haplotypes. Admixture estimates revealed that the main genetic components in the state of Guanajuato are Native American (50.64 ± 2.11 by ML, 43.35 of Native American haplotypes) and European (44.14 ± 1.14 by ML; 39.35 of European haplotypes), while African genetic component is less apparent (5.22 ± 2.08 by ML; 8.36 of African haplotypes).

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Language(s): eng - English
 Dates: 2019-06-14
 Publication Status: Published online
 Pages: 3
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.humimm.2019.06.002
Other: shh2257
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Title: Human Immunology
Source Genre: Journal
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Publ. Info: New York, N.Y. : Elsevier
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 0198-8859
CoNE: https://pure.mpg.de/cone/journals/resource/954925492912