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  Testosterone imbalance may link depression and increased body weight in premenopausal women

Stanikova, D., Zsido, R., Luck, T., Pabst, A., Enzenbach, C., Bae, Y. J., et al. (2019). Testosterone imbalance may link depression and increased body weight in premenopausal women. Translational Psychiatry, 9: 160. doi:10.1038/s41398-019-0487-5.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-CA6D-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-4FCD-E
Genre: Journal Article

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 Creators:
Stanikova, Daniela 1, 2, 3, Author
Zsido, Rachel4, Author              
Luck, Tobias 5, 6, Author
Pabst, Alexander 1, Author
Enzenbach, Cornelia 5, 7, Author
Bae, Yoon Ju 8, Author
Thiery, Joachim 5, 8, Author
Ceglarek, Uta 5, 8, Author
Engel, Christoph 5, 7, Author
Wirkner, Kerstin 5, Author
Stanik, Juraj 1, 2, 9, Author
Kratzsch, Juergen 8, Author
Villringer, Arno3, 10, Author              
Riedel-Heller, Steffi G. 6, Author
Sacher, Julia3, 10, Author              
Affiliations:
1Biomedical Research Center, Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovakia, ou_persistent22              
2Department of Pediatrics, Medical Faculty, Comenius University, Bratislava, Slovakia, ou_persistent22              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
4Department of Economic & Social Sciences, University of Applied Sciences Nordhausen, Germany, ou_persistent22              
5Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22              
6Institute of Social Medicine, Occupational Health and Public Health (ISAP), University Hospital Leipzig, Germany, ou_persistent22              
7Institute for Medical Informatics, Statistics and Epidemiology (IMISE), University of Leipzig, Germany, ou_persistent22              
8Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (ILM), University of Leipzig, Germany, ou_persistent22              
9Center for Pediatric Research Leipzig (CPL), University Hospital Leipzig, Germany, ou_persistent22              
10Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              

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 Abstract: Accumulating evidence supports a link between depression and being overweight in women. Given previously reported sex differences in fat accumulation and depression prevalence, as well as the likely role of sex hormones in both overweight and mood disorders, we hypothesised that the depression-overweight association may be mediated by sex hormones. To this end, we investigated the association of being overweight with depression, and then considered the role of sex hormones in relation to being overweight and depression in a large population-based cohort. We included a total of 3124 women, 970 premenopausal and 2154 postmenopausal from the LIFE-Adult cohort study in our analyses. We evaluated associations between being overweight (BMI >25 kg/m2), sex hormone levels, and depressive symptomatology according to Centre for Epidemiologic Studies Depression (CES-D) scores, and explored mediation of depression in a mediation model. Being overweight was significantly associated with depressive symptoms in premenopausal but not postmenopausal women. Both premenopausal and postmenopausal overweight women had higher free testosterone levels compared with normal weight women. Premenopausal women with depressive symptomatology had higher free testosterone levels compared to women without. We found a significant mediation effect of depressive symptomatology in overweight premenopausal women through free testosterone level. These findings highlight the association between being overweight and depressed, and suggest that high free testosterone levels may play a significant role in depression of overweight premenopausal women. Based on this, pharmacological approaches targeting androgen levels in overweight depressed females, in particular when standard anti-depressive treatments fail, could be of specific clinical relevance.

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Language(s): eng - English
 Dates: 2019-03-232018-09-262019-04-022019-06-07
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1038/s41398-019-0487-5
PMID: 31175272
 Degree: -

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Funding organization : LIFE–Leipzig Research Center for Civilization Diseases, University of Leipzig
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Funding organization : European Union (EU)
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Funding program : European Social Fund
Funding organization : European Commission (EC)
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Funding program : European Regional Development Fund
Funding organization : European Commission (EC)
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Funding organization : Free State of Saxony
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Grant ID : 01EO1501
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Funding organization : IFB Adiposity Diseases, German Federal Ministry of Education and Research (BMBF)
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Funding organization : Max Planck Society
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Funding program : Branco Weiss Fellowship - Society in Science
Funding organization : ETH Zurich
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Funding program : NARSAD Young Investigator Award
Funding organization : Brain and Behavior Research Foundation
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Funding organization : European Society for Paediatric Endocrinology (ESPE)

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Title: Translational Psychiatry
  Abbreviation : Transl Psychiatry
Source Genre: Journal
 Creator(s):
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Publ. Info: Nature Pub. Group
Pages: - Volume / Issue: 9 Sequence Number: 160 Start / End Page: - Identifier: ISSN: 2158-3188
CoNE: https://pure.mpg.de/cone/journals/resource/2158-3188