日本語
 
Help Privacy Policy ポリシー/免責事項
  詳細検索ブラウズ

アイテム詳細

登録内容を編集ファイル形式で保存
 
 
ダウンロード電子メール
 タグ情報を表示リリース履歴を表示詳細要約
  Testosterone imbalance may link depression and increased body weight in premenopausal women

Stanikova, D., Zsido, R., Luck, T., Pabst, A., Enzenbach, C., Bae, Y. J., Thiery, J., Ceglarek, U., Engel, C., Wirkner, K., Stanik, J., Kratzsch, J., Villringer, A., Riedel-Heller, S. G., & Sacher, J. (2019). Testosterone imbalance may link depression and increased body weight in premenopausal women. Translational Psychiatry, 9:. doi:10.1038/s41398-019-0487-5.

Item is

 

表示: 全項目 非表示: 全項目

基本情報

表示: 非表示:
アイテムのパーマリンク: https://hdl.handle.net/21.11116/0000-0003-CA6D-0 版のパーマリンク: https://hdl.handle.net/21.11116/0000-0006-7855-4
資料種別: 学術論文

ファイル

表示: ファイル
非表示: ファイル
:
Stanikova_2019.pdf (出版社版), 781KB
表示   保存
ファイルのパーマリンク:
https://hdl.handle.net/21.11116/0000-0003-CA6F-E
ファイル名:
Stanikova_2019.pdf
説明:
-
OA-Status:
閲覧制限:
公開
MIMEタイプ / チェックサム:
application/pdf / [MD5]
技術的なメタデータ:
表示
著作権日付:
-
著作権情報:
-
CCライセンス:
-

関連URL

表示:

作成者

表示:
非表示:
 作成者:
Stanikova, Daniela 1, 2, 3, 著者
Zsido, Rachel4, 5, 著者           
Luck, Tobias 6, 7, 著者
Pabst, Alexander 3, 著者
Enzenbach, Cornelia 7, 8, 著者
Bae, Yoon Ju 9, 著者
Thiery, Joachim 7, 9, 著者
Ceglarek, Uta 7, 9, 著者
Engel, Christoph 7, 8, 著者
Wirkner, Kerstin 7, 著者
Stanik, Juraj 1, 2, 10, 著者
Kratzsch, Juergen 9, 著者
Villringer, Arno5, 11, 著者           
Riedel-Heller, Steffi G. 3, 著者
Sacher, Julia4, 5, 11, 著者           
所属:
1Biomedical Research Center, Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovakia, ou_persistent22              
2Department of Pediatrics, Medical Faculty, Comenius University, Bratislava, Slovakia, ou_persistent22              
3Institute of Social Medicine, Occupational Health and Public Health (ISAP), University Hospital Leipzig, Germany, ou_persistent22              
4Minerva Research Group EGG (Emotion & neuroimaGinG) Lab, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3230775              
5Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634549              
6Department of Economic & Social Sciences, University of Applied Sciences Nordhausen, Germany, ou_persistent22              
7Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22              
8Institute for Medical Informatics, Statistics and Epidemiology (IMISE), University of Leipzig, Germany, ou_persistent22              
9Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (ILM), University of Leipzig, Germany, ou_persistent22              
10Center for Pediatric Research Leipzig (CPL), University Hospital Leipzig, Germany, ou_persistent22              
11Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              

内容説明

表示:
非表示:
キーワード: -
 要旨: Accumulating evidence supports a link between depression and being overweight in women. Given previously reported sex differences in fat accumulation and depression prevalence, as well as the likely role of sex hormones in both overweight and mood disorders, we hypothesised that the depression-overweight association may be mediated by sex hormones. To this end, we investigated the association of being overweight with depression, and then considered the role of sex hormones in relation to being overweight and depression in a large population-based cohort. We included a total of 3124 women, 970 premenopausal and 2154 postmenopausal from the LIFE-Adult cohort study in our analyses. We evaluated associations between being overweight (BMI >25 kg/m2), sex hormone levels, and depressive symptomatology according to Centre for Epidemiologic Studies Depression (CES-D) scores, and explored mediation of depression in a mediation model. Being overweight was significantly associated with depressive symptoms in premenopausal but not postmenopausal women. Both premenopausal and postmenopausal overweight women had higher free testosterone levels compared with normal weight women. Premenopausal women with depressive symptomatology had higher free testosterone levels compared to women without. We found a significant mediation effect of depressive symptomatology in overweight premenopausal women through free testosterone level. These findings highlight the association between being overweight and depressed, and suggest that high free testosterone levels may play a significant role in depression of overweight premenopausal women. Based on this, pharmacological approaches targeting androgen levels in overweight depressed females, in particular when standard anti-depressive treatments fail, could be of specific clinical relevance.

資料詳細

表示:
非表示:
言語: eng - English
 日付: 2019-03-232018-09-262019-04-022019-06-07
 出版の状態: オンラインで出版済み
 ページ: -
 出版情報: -
 目次: -
 査読: 査読あり
 識別子（DOI, ISBNなど）: DOI: 10.1038/s41398-019-0487-5
PMID: 31175272
 学位: -

関連イベント

表示:

訴訟

表示:

Project information

表示: 非表示:
Project name : -
Grant ID : -
Funding program : -
Funding organization : LIFE–Leipzig Research Center for Civilization Diseases, University of Leipzig
Project name : -
Grant ID : -
Funding program : -
Funding organization : European Union (EU)
Project name : -
Grant ID : -
Funding program : European Social Fund
Funding organization : European Commission (EC)
Project name : -
Grant ID : -
Funding program : European Regional Development Fund
Funding organization : European Commission (EC)
Project name : -
Grant ID : -
Funding program : -
Funding organization : Free State of Saxony
Project name : -
Grant ID : 01EO1501
Funding program : -
Funding organization : IFB Adiposity Diseases, German Federal Ministry of Education and Research (BMBF)
Project name : -
Grant ID : -
Funding program : -
Funding organization : Max Planck Society
Project name : -
Grant ID : -
Funding program : Branco Weiss Fellowship - Society in Science
Funding organization : ETH Zurich
Project name : -
Grant ID : -
Funding program : NARSAD Young Investigator Award
Funding organization : Brain and Behavior Research Foundation
Project name : -
Grant ID : -
Funding program : -
Funding organization : European Society for Paediatric Endocrinology (ESPE)

出版物 1

表示:
非表示:
出版物名: Translational Psychiatry
  省略形 : Transl Psychiatry
種別: 学術雑誌
 著者・編者:
所属:
出版社, 出版地: Nature Pub. Group
ページ: - 巻号: 9 通巻号: 160 開始・終了ページ: - 識別子（ISBN, ISSN, DOIなど）: ISSN: 2158-3188
CoNE: https://pure.mpg.de/cone/journals/resource/2158-3188