English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Whole‐brain snapshot CEST imaging at 7 T using 3D‐EPI

Akbey, S., Ehses, P., Stirnberg, R., Zaiss, M., & Stöcker, T. (2019). Whole‐brain snapshot CEST imaging at 7 T using 3D‐EPI. Magnetic Resonance in Medicine, 82(5), 1741-1752. doi:10.1002/mrm.27866.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0003-CAD3-B Version Permalink: http://hdl.handle.net/21.11116/0000-0004-6E16-9
Genre: Journal Article

Files

show Files

Locators

show
hide
Description:
-

Creators

show
hide
 Creators:
Akbey, S, Author
Ehses, P, Author              
Stirnberg, R, Author
Zaiss, M1, 2, Author              
Stöcker, T, Author
Affiliations:
1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

Content

show
hide
Free keywords: -
 Abstract: Purpose The aim of this work is to develop a fast and robust CEST sequence in order to allow the acquisition of a whole‐brain imaging volume after a single preparation block (snapshot acquisition). Methods A 3D‐CEST sequence with an optimized 3D‐EPI readout module was developed, which acquires the complete k‐space data following a single CEST preparation for 1 saturation offset. Whole‐brain mapping of the Z‐spectrum with 2 mm isotropic resolution is achieved at 68 saturation frequencies in 5 minutes (4.33 s per offset). We analyzed the urn:x-wiley:07403194:media:mrm27866:mrm27866-math-0002 distribution in order to optimize urn:x-wiley:07403194:media:mrm27866:mrm27866-math-0003 correction and to provide accurate CEST quantification across the whole brain. Results We obtained maps for 3 different CEST contrasts from 4 healthy subjects. Based on our urn:x-wiley:07403194:media:mrm27866:mrm27866-math-0004 distribution analysis, we conclude that 3 urn:x-wiley:07403194:media:mrm27866:mrm27866-math-0005 sampling points allow for sufficient compensation of urn:x-wiley:07403194:media:mrm27866:mrm27866-math-0006 variations across most of the brain. Two brain regions, the cerebellum and the temporal lobes, are difficult to quantify at 7 T due to very low urn:x-wiley:07403194:media:mrm27866:mrm27866-math-0007 that was achieved in these regions. Conclusions The proposed sequence enables robust acquisition of 2 mm isotropic whole‐brain CEST maps at 7 Tesla within a total scan time of 16 minutes.

Details

show
hide
Language(s):
 Dates: 2019-062019-11
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1002/mrm.27866
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Magnetic Resonance in Medicine
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York : Wiley-Liss
Pages: - Volume / Issue: 82 (5) Sequence Number: - Start / End Page: 1741 - 1752 Identifier: ISSN: 0740-3194
CoNE: https://pure.mpg.de/cone/journals/resource/954925538149