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  Large-scale reorganization of the tonotopic map in mouse auditory midbrain revealed by MRI

Yu, X., Sanes, D., Aristizabal, O., Wadghiri, Y., & Turnbull, D. (2007). Large-scale reorganization of the tonotopic map in mouse auditory midbrain revealed by MRI. Proceedings of the National Academy of Sciences of the United States of America, 104(29), 12193-12198. doi:10.1073/pnas.0700960104.

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Yu, X1, Author              
Sanes, DH, Author
Aristizabal, O, Author
Wadghiri, YZ, Author
Turnbull, DH, Author
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1External Organizations, ou_persistent22              

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 Abstract: The cortex is thought to be the primary site of sensory plasticity, particularly during development. Here, we report that large-scale reorganization of the mouse auditory midbrain tonotopic map is induced by a specific sound-rearing environment consisting of paired low- (16 kHz) and high-frequency (40 kHz) tones. To determine the potential for plasticity in the mouse auditory midbrain, we used manganese-enhanced MRI to analyze the midbrain tonotopic maps of control mice during normal development and mice reared in the two-tone (16 + 40 kHz) environment. We found that the tonotopic map emerged during the third postnatal week in normal mice. Before 3 weeks, a larger percentage of auditory midbrain responded to each of the suprathreshold test frequencies, despite the fact that the primary afferent projections are in place even before hearing onset. By 3 weeks, the midbrain tonotopic map of control mice was established, and manganese-enhanced MRI showed a clear separation between the 16- and 40-kHz responses. Two-tone rearing dramatically altered the appearance of these discrete frequency-specific responses. A significant volume of the auditory midbrain became responsive to both rearing frequencies, resulting in a large-scale reorganization of the tonotopic map. These results indicate that developmental plasticity occurs on a much greater scale than previously appreciated in the mammalian auditory midbrain.

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 Dates: 2007-07
 Publication Status: Published in print
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 Rev. Type: -
 Identifiers: DOI: 10.1073/pnas.0700960104
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Title: Proceedings of the National Academy of Sciences of the United States of America
  Other : Proc. Acad. Sci. USA
  Other : Proc. Acad. Sci. U.S.A.
  Other : Proceedings of the National Academy of Sciences of the USA
  Abbreviation : PNAS
Source Genre: Journal
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Publ. Info: Washington, D.C. : National Academy of Sciences
Pages: - Volume / Issue: 104 (29) Sequence Number: - Start / End Page: 12193 - 12198 Identifier: ISSN: 0027-8424
CoNE: https://pure.mpg.de/cone/journals/resource/954925427230