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  Regulation of anterior insular cortex activity using real-time fMRI

Caria, A., Veit, R., Sitaram, R., Lotze, M., Weiskopf, N., Grodd, W., et al. (2007). Regulation of anterior insular cortex activity using real-time fMRI. NeuroImage, 35(3), 1238-1246. doi:10.1016/j.neuroimage.2007.01.018.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-CBF9-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-CBFA-F
Genre: Journal Article

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 Creators:
Caria, A, Author
Veit, R1, 2, Author              
Sitaram, R, Author              
Lotze, M, Author
Weiskopf, N, Author
Grodd, W, Author              
Birbaumer, N, Author
Affiliations:
1Former Department MRZ, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528700              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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Free keywords: Self-regulation; Physiological regulation; Real-time fMRI; Brain–computer interface; Neurofeedback; Blood oxygen level-dependent; Insula
 Abstract: Recent advances in functional magnetic resonance imaging (fMRI) data acquisition and processing techniques have made real-time fMRI (rtfMRI) of localized brain areas feasible, reliable and less susceptible to artefacts. Previous studies have shown that healthy subjects learn to control local brain activity with operant training by using rtfMRI-based neurofeedback. In the present study, we investigated whether healthy subjects could voluntarily gain control over right anterior insular activity. Subjects were provided with continuously updated information of the target ROI's level of activation by visual feedback. All participants were able to successfully regulate BOLD-magnitude in the right anterior insular cortex within three sessions of 4 min each. Training resulted in a significantly increased activation cluster in the anterior portion of the right insula across sessions. An increased activity was also found in the left anterior insula but the percent signal change was lower than in the target ROI. Two different control conditions intended to assess the effects of non-specific feedback and mental imagery demonstrated that the training effect was not due to unspecific activations or non feedback-related cognitive strategies. Both control groups showed no enhanced activation across the sessions, which confirmed our main hypothesis that rtfMRI feedback is area-specific. The increased activity in the right anterior insula during training demonstrates that the effects observed are anatomically specific and self-regulation of right anterior insula only is achievable. This is the first group study investigating the volitional control of emotionally relevant brain region by using rtfMRI training and confirms that self-regulation of local brain activity with rtfMRI is possible.

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Language(s): eng - English
 Dates: 2007-04
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1016/j.neuroimage.2007.01.018
 Degree: -

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Title: NeuroImage
Source Genre: Journal
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Affiliations:
Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 35 (3) Sequence Number: - Start / End Page: 1238 - 1246 Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166