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  Acute psychosocial stress increases serum BDNF levels: An antagonistic relation to cortisol but no group differences after mental training

Linz, R., Puhlmann, L. M., Apostolakou, F., Mantzou, E., Papassotiriou, I., Chrousos, G. P., et al. (2019). Acute psychosocial stress increases serum BDNF levels: An antagonistic relation to cortisol but no group differences after mental training. Neuropsychopharmacology. doi:10.1038/s41386-019-0391-y.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-FA72-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-FA73-2
Genre: Journal Article

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 Creators:
Linz, Roman1, 2, Author              
Puhlmann, Lara M.1, 2, Author              
Apostolakou, F.3, Author
Mantzou, E.4, Author
Papassotiriou, I. 3, Author
Chrousos, G. P. 4, Author
Engert, Veronika1, 2, Author              
Singer, Tania2, 5, Author              
Affiliations:
1Research Group Social Stress and Family Health, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3025667              
2Department Social Neuroscience, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634552              
3Department of Clinical Biochemistry, “Aghia Sophia” Children’s Hospital, Athens, Greece, ou_persistent22              
4First Department of Pediatrics, School of Medicine, “Aghia Sofia” General Children’s Hospital, Athens, Greece, ou_persistent22              
5Social Neuroscience Lab, Berlin, Germany, ou_persistent22              

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 Abstract: Brain-derived neurotrophic factor (BDNF) is an essential facilitator of neuronal plasticity. By counteracting the adverse effects of excessive stress-induced glucocorticoid signaling, BDNF has been implicated as a resilience factor to psychopathology caused by chronic stress. Insights into the effects of acute stress on peripheral BDNF levels in humans are inconclusive. The short-term interplay between BDNF and cortisol in response to acute psychosocial stress remains unexplored. Furthermore, it is unknown whether mental training that is effective at reducing cortisol reactivity can also influence BDNF during acute stress. In the current study, we investigated serum BDNF levels during an acute psychosocial stress paradigm, the Trier Social Stress Test (TSST), in 301 healthy participants (178 women, mean age = 40.65) recruited as part of the ReSource Project, a large-scale mental training study consisting of three distinct 3-month training modules. Using a cross-sectional study design, we first examined the relationship between BDNF and salivary cortisol in a control group with no mental training. Subsequent analyses focused on differences in BDNF stress levels between control and mental training groups. We show that serum BDNF is indeed stress-sensitive, characterized by a significant post-stress increase and subsequent decline to recovery. While respective increases in BDNF and cortisol were not associated, we found two indications for an antagonistic relationship. Higher BDNF peaks after stress were associated with steeper cortisol recovery. On the other hand, the magnitude of the cortisol stress response was linked to steeper BDNF recovery after stress. BDNF levels were not modulated by any of the mental training modules. Providing novel evidence for the dynamics of BDNF and cortisol during acute stress, our findings may further inform research on the physiological mechanisms involved in stress chronification and the associated health risks.

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Language(s): eng - English
 Dates: 2019-03-242018-11-232019-04-042019-04-16
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1038/s41386-019-0391-y
PMID: 30991416
Other: Epub ahead of print
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Project name : Plasticity of the Empathic Brain: Structural and Functional MRI Studies on the Effect of Empathy Training on the Human Brain and Prosocial Behaviour / EMPATHICBRAIN
Grant ID : 205557
Funding program : Funding Programme 7
Funding organization : European Commission (EC)
Project name : -
Grant ID : -
Funding program : -
Funding organization : Max Planck Society

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Title: Neuropsychopharmacology
Source Genre: Journal
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Publ. Info: New York, NY : No longer published by Elsevier
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 0893-133X
CoNE: https://pure.mpg.de/cone/journals/resource/954925558485