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  Neural correlates of socio-emotional perception in 22q11.2 deletion syndrome

Dubourg, L., Vrticka, P., Debbané, M., Chambaz, L., Eliez, S., & Schneider, M. (2018). Neural correlates of socio-emotional perception in 22q11.2 deletion syndrome. Journal of Neurodevelopmental Disorders, 10: 13. doi:10.1186/s11689-018-9232-2.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-F305-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-F306-4
Genre: Journal Article

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 Creators:
Dubourg, Lydia1, Author
Vrticka, Pascal2, Author              
Debbané, Martin 1, 3, 4, Author
Chambaz, Léa 1, Author
Eliez, Stephan 1, 5, Author
Schneider, Maude 6, Author
Affiliations:
1Department of Psychiatry, School of Medicine, University of Geneva, Switzerland, ou_persistent22              
2Department Social Neuroscience, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634552              
3Developmental Clinical Psychology Research Unit, Faculty of Psychology and Educational Sciences, University of Geneva, Switzerland, ou_persistent22              
4Research Department of Clinical, Educational and Health Psychology, University College London, United Kingdom, ou_persistent22              
5Department of Genetic Medicine and Development, University of Geneva, Switzerland, ou_persistent22              
6Center for Contextual Psychiatry, Department of Neurosciences, Katholieke Universiteit Leuven, Belgium, ou_persistent22              

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Free keywords: 22q11.2 deletion syndrome; Default mode network; Socio-emotional perception; fMRI
 Abstract: Background Social impairments are described as a common feature of the 22q11.2 deletion syndrome (22q11DS). However, the neural correlates underlying these impairments are largely unknown in this population. In this study, we investigated neural substrates of socio-emotional perception. Methods We used event-related functional magnetic resonance imaging (fMRI) to explore neural activity in individuals with 22q11DS and healthy controls during the visualization of stimuli varying in social (social or non-social) or emotional (positive or negative valence) content. Results Neural hyporesponsiveness in regions of the default mode network (inferior parietal lobule, precuneus, posterior and anterior cingulate cortex and frontal regions) in response to social versus non-social images was found in the 22q11DS population compared to controls. A similar pattern of activation for positive and negative emotional processing was observed in the two groups. No correlation between neural activation and social functioning was observed in patients with the 22q11DS. Finally, no social × valence interaction impairment was found in patients. Conclusions Our results indicate atypical neural correlates of social perception in 22q11DS that appear to be independent of valence processing. Abnormalities in the social perception network may lead to social impairments observed in 22q11DS individuals.

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Language(s): eng - English
 Dates: 2017-12-062018-03-232018-04-10
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1186/s11689-018-9232-2
PMID: 29631546
PMC: PMC5891973
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Project name : -
Grant ID : 324730_144260
Funding program : -
Funding organization : Swiss National Science Foundation
Project name : NCCR Synapsy
Grant ID : 51NF40–158776 ; 100014–135311/1
Funding program : -
Funding organization : Swiss National Science Foundation

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Title: Journal of Neurodevelopmental Disorders
Source Genre: Journal
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Publ. Info: BioMed Central
Pages: - Volume / Issue: 10 Sequence Number: 13 Start / End Page: - Identifier: ISSN: 1866-1955
CoNE: https://pure.mpg.de/cone/journals/resource/1866-1955