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  Psychological, endocrine and neural responses to social evaluation in subclinical depression

Dedovic, K., Duchesne, A., Engert, V., Lue, S. D., Andrews, J., Efanov, S. I., et al. (2014). Psychological, endocrine and neural responses to social evaluation in subclinical depression. Social Cognitive and Affective Neuroscience, 9(10), 1632-1644. doi:10.1093/scan/nst151.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-FF50-4 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-FF51-3
Genre: Journal Article

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 Creators:
Dedovic, Katarina1, Author
Duchesne, Annie2, Author
Engert, Veronika3, Author              
Lue, Sonja D. 2, Author
Andrews, Julie2, Author
Efanov, Simona I. 4, Author
Beaudry, Thomas2, Author
Pruessner, Jens C.2, 5, Author
Affiliations:
1Social and Affective Neuroscience Laboratory, Department of Psychology, University of California, Los Angeles, CA, USA, ou_persistent22              
2Douglas Mental Health University Institute, McGill University, Montréal, QC, Canada, ou_persistent22              
3Department Social Neuroscience, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634552              
4American School of Professional Psychology, Washington, DC, USA, ou_persistent22              
5McGill Centre for Studies in Aging, McGill University, Montréal, QC, Canada, ou_persistent22              

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Free keywords: Subclinical depression; Subgenual anterior cingulate cortex; Social evaluation; Cortisol; Vulnerability
 Abstract: This study aimed to identify vulnerability patterns in psychological, physiological and neural responses to mild psychosocial challenge in a population that is at a direct risk of developing depression, but who has not as yet succumbed to the full clinical syndrome. A group of healthy and a group of subclinically depressed participants underwent a modified Montreal Imaging Stress task (MIST), a mild neuroimaging psychosocial task and completed state self-esteem and mood measures. Cortisol levels were assessed throughout the session. All participants showed a decrease in performance self-esteem levels following the MIST. Yet, the decline in performance self-esteem levels was associated with increased levels of anxiety and confusion in the healthy group, but increased levels of depression in the subclinical group, following the MIST. The subclinical group showed overall lower cortisol levels compared with the healthy group. The degree of change in activity in the subgenual anterior cingulate cortex in response to negative evaluation was associated with increased levels of depression in the whole sample. Findings suggest that even in response to a mild psychosocial challenge, those individuals vulnerable to depression already show important maladaptive response patterns at psychological and neural levels. The findings point to important targets for future interventions.

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Language(s): eng - English
 Dates: 2013-10-212014-10
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1093/scan/nst151
PMID: 24078020
PMC: PMC4187276
Other: Epub 2013
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Title: Social Cognitive and Affective Neuroscience
Source Genre: Journal
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Pages: - Volume / Issue: 9 (10) Sequence Number: - Start / End Page: 1632 - 1644 Identifier: ISSN: 1749-5016
CoNE: /journals/resource/1000000000223760