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  Mechanisms and biomedical implications of –1 programmed ribosome frameshifting on viral and bacterial mRNAs.

Korniy, N., Samatova, E. N., Anokhina, M. M., Peske, F., & Rodnina, M. V. (2019). Mechanisms and biomedical implications of –1 programmed ribosome frameshifting on viral and bacterial mRNAs. FEBS Letters, 593(13), 1468-1482. doi:10.1002/1873-3468.13478.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-CC5E-F Version Permalink: http://hdl.handle.net/21.11116/0000-0003-FE43-4
Genre: Journal Article

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3070050.pdf (Publisher version), 4MB
 
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Korniy, N.1, Author              
Samatova, E. N.1, Author              
Anokhina, M. M., Author
Peske, F.1, Author              
Rodnina, M. V.1, Author              
Affiliations:
1Department of Physical Biochemistry, MPI for biophysical chemistry, Max Planck Society, ou_578598              

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 Abstract: Some proteins are expressed as a result of a ribosome frameshifting event that is facilitated by a slippery site and downstream secondary structure elements in the mRNA. This review summarizes recent progress in understanding mechanisms of –1 frameshifting in several viral genes, including IBV 1a/1b, HIV‐1 gag‐pol, and SFV 6K, and in E. coli dnaX. The exact frameshifting route depends on the availability of aminoacyl‐tRNAs: the ribosome normally slips into the –1‐frame during tRNA translocation, but can also frameshift during decoding at condition when aminoacyl‐tRNA is in limited supply. Different frameshifting routes and additional slippery sites allow viruses to maintain a constant production of their key proteins. The emerging idea that tRNA pools are important for frameshifting provides new direction for developing antiviral therapies.

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Language(s): eng - English
 Dates: 2019-06-102019-07
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1002/1873-3468.13478
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Title: FEBS Letters
Source Genre: Journal
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Pages: - Volume / Issue: 593 (13) Sequence Number: - Start / End Page: 1468 - 1482 Identifier: -