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  Hiatal hernias in patients with GERD-like symptoms: Evaluation of dynamic real-time MRI vs endoscopy.

Seif Amir Hosseini, A., Uhlig, J., Streit, U., Uhlig, A., Sprenger, T., Wedi, E., et al. (2019). Hiatal hernias in patients with GERD-like symptoms: Evaluation of dynamic real-time MRI vs endoscopy. European Radiology, 29(12), 6653-6661. doi:10.1007/s00330-019-06284-8.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-CFC4-7 Version Permalink: http://hdl.handle.net/21.11116/0000-0005-0B5C-9
Genre: Journal Article

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 Creators:
Seif Amir Hosseini, A., Author
Uhlig, J., Author
Streit, U., Author
Uhlig, A., Author
Sprenger, T., Author
Wedi, E., Author
Ellenrieder, V., Author
Ghadimi, M., Author
Uecker, M., Author
Voit, D.1, Author              
Frahm, J.1, Author              
Lotz, J., Author
Biggemann, L., Author
Affiliations:
1Biomedical NMR Research GmbH, MPI for biophysical chemistry, Max Planck Society, ou_578634              

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Free keywords: EDG; Endoscopy; Gastroesophageal reflux disease; Hiatal hernia; Magnetic resonance imaging
 Abstract: PURPOSE: To assess the diagnostic potential of real-time MRI for assessment of hiatal hernias in patients with GERD-like symptoms compared to endoscopy. MATERIAL AND METHODS: One hundred eight patients with GERD-like symptoms were included in this observational cohort study between 2015 and 2017. Real-time MRI was performed at 3.0 Tesla with temporal resolution of 40 ms, dynamically visualizing the esophageal transport of a pineapple juice bolus, its passage through the gastroesophageal junction, and functional responses during Valsalva maneuver. Hernia detection on MRI and endoscopy was calculated using contingency tables with diagnosis of hernia on either modality as reference. RESULTS: Of 108 patients, 107 underwent successful MRI without adverse events; 1 examination was aborted to inability to swallow pineapple juice in supine position. No perforation or acute bleeding occurred during endoscopy. Median examination time was 15 min. Eighty-five patients (79.4%) were diagnosed with hiatal hernia on either real-time MRI or endoscopy. Forty-six hernias were visible on both modalities. Seventeen hernias were evident exclusively on MRI, and 22 exclusively on endoscopy. Sixteen of the 63 MRI-detected hernias (25.4%) were detectable only during Valsalva maneuver, which were smaller compared to hernias at rest (median - 13.5 vs - 33.0 mm, p < 0.001). Diagnostic accuracy for hernia detection was comparable for MRI and endoscopy (sensitivity 74% vs 80%, p = 0.4223; specificity 100% vs 100%, p > 0.99). CONCLUSION: Real-time MRI is a fast and safe modality for assessment of the gastroesophageal junction, without radiation exposure or administration of gadolinium-based contrast media. Although MRI and endoscopy yield comparable diagnostic accuracy, dynamic MRI sequences are able to visualize hiatal hernias that were occult on static MRI sequences or endoscopy in a relevant number of cases. KEY POINTS: • Real-time MRI is a safe and fast imaging modality for examination of the gastroesophageal junction, combining anatomical and functional information for enhanced detection of hiatal hernias. • Real-time MRI and endoscopy yield comparably high diagnostic accuracy: real-time MRI visualizes hiatal hernias that were occult on endoscopy in a relevant number of patients; however, several hiatal hernias detected on endoscopy were occult on real-time MRI. • There is clinical potential of real-time MR imaging in patients with GERD-like symptoms and equivocal findings on endoscopy or pH-metry, for anatomical visualization in patients planned for surgical intervention, or those with suspected fundoplication failures.

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Language(s): eng - English
 Dates: 2019-06-112019-12
 Publication Status: Published in print
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1007/s00330-019-06284-8
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Title: European Radiology
Source Genre: Journal
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Pages: - Volume / Issue: 29 (12) Sequence Number: - Start / End Page: 6653 - 6661 Identifier: -