LRIT1 Modulates Adaptive Changes in Synaptic Communication of Cone 
Photoreceptors

Sarria, Ignacio; Cao, Yan; Wang, Yuchen; Ingram, Norianne T.; Orlandi, Cesare; Kamasawa, Naomi; Kolesnikov, Alexander V.; Pahlberg, Johan; Kefalov, Vladimir J.; Sampath, Alapakkam P.; Martemyanov, Kirill A.

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LRIT1 Modulates Adaptive Changes in Synaptic Communication of Cone Photoreceptors

Sarria, I., Cao, Y., Wang, Y., Ingram, N. T., Orlandi, C., Kamasawa, N., et al. (2018). LRIT1 Modulates Adaptive Changes in Synaptic Communication of Cone Photoreceptors. Cell Reports, 3562-3573. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/29590623.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0003-D509-3 Version Permalink: https://hdl.handle.net/21.11116/0000-0003-D56C-4

Genre: Journal Article

Alternative Title : Cell Reports

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Creators:
Sarria, Ignacio, Author
Cao, Yan, Author
Wang, Yuchen, Author
Ingram, Norianne T., Author
Orlandi, Cesare, Author
Kamasawa, Naomi¹, Author
Kolesnikov, Alexander V., Author
Pahlberg, Johan, Author
Kefalov, Vladimir J., Author
Sampath, Alapakkam P., Author
Martemyanov, Kirill A., Author

Affiliations:
1Max Planck Florida Institute for Neuroscience, Max Planck Society, One Max Planck Way, Jupiter FL 33458, USA, ou_1950288

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Free keywords: synaptic transmission, cone photoreceptors, G protein coupled receptors, leucine-rich repeat proteins, ON-bipolar neurons

Abstract: Cone photoreceptors scale dynamically the sensitivity of responses to maintain responsiveness across wide range of changes in luminance. Synaptic changes contribute to this adaptation, but how this process is coordinated at the molecular level is poorly understood. Here, we report that a cell adhesion-like molecule, LRIT1, is enriched selectively at cone photoreceptor synapses where it engages in a trans-synaptic interaction with mGluR6, the principal receptor in postsynaptic ON-bipolar cells. The levels of LRIT1 are regulated by the neurotransmitter release apparatus that controls photoreceptor output. Knockout of LRIT1 in mice increases the sensitivity of cone synaptic signaling while impairing its ability to adapt to background light without overtly influencing the morphology or molecular composition of photoreceptor synapses. Accordingly, mice lacking LRIT1 show visual deficits under conditions requiring temporally challenging discrimination of visual signals in steady background light. These observations reveal molecular mechanisms involved in scaling synaptic communication in the retina.

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Dates: Date issued: 2018

Publication Status: Issued

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Identifiers: URI: http://www.ncbi.nlm.nih.gov/pubmed/29590623

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Title: Cell Reports

Source Genre: Journal

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Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 3562 - 3573 Identifier: -