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  Genetic diversity of HLA system in two populations from Colima, Mexico: Colima city and rural Colima

Barquera Lozano, R. J., Hernández-Zaragoza, D. I., Arellano-Prado, F. P., Goné-Vázquez, I., Clayton, S., Arrieta-Bolaños, E., et al. (2019). Genetic diversity of HLA system in two populations from Colima, Mexico: Colima city and rural Colima. Human Immunology. doi:10.1016/j.humimm.2019.06.004.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-D653-E Version Permalink: http://hdl.handle.net/21.11116/0000-0003-D654-D
Genre: Journal Article

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Barquera Lozano, Rodrigo José1, Author              
Hernández-Zaragoza, Diana Iraíz, Author
Arellano-Prado, Francia Paulina, Author
Goné-Vázquez, Isis, Author
Clayton, Stephen1, Author              
Arrieta-Bolaños, Esteban, Author
Escobedo-Ruíz, Araceli, Author
García-Arias, Víctor Eduardo, Author
Bravo-Acevedo, Alicia, Author
Rodríguez-López, Marla Estefanía, Author
Sánchez-Fernández, María Guadalupe de Jesús, Author
Sandoval-Sandoval, Mario J., Author
Gómez-Navarro, Benjamín, Author
Zúñiga, Joaquín, Author
Yunis, Edmond J., Author
Bekker-Méndez, Carolina, Author
Granados, Julio, Author
Affiliations:
1Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2074310              

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Free keywords: Admixture, Colima, HLA, Immunogenetics, Population genetics
 Abstract: We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 104 Mexicans from the state of Colima living in the city of Colima (N = 61) and rural communities (N = 43), to obtain information regarding allelic and haplotypic frequencies. We find that the most frequent haplotypes in the state of Colima include eight Native American, two European and one African haplotype. Admixture estimates revealed that the main genetic components in the state are Native American (52.74 ± 3.88 by ML; 48.10 of Native American haplotypes) and European (37.52 ± 8.94 by ML; 26.66 of European haplotypes), and a relatively high African genetic component (9.74 ± 8.40 by ML; 11.91 of African haplotypes). © 2019 American Society for Histocompatibility and Immunogenetics

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 Dates: 2019-06-06
 Publication Status: Published online
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 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.humimm.2019.06.004
Other: shh2265
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Title: Human Immunology
Source Genre: Journal
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Publ. Info: New York, N.Y. : Elsevier
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 0198-8859
CoNE: https://pure.mpg.de/cone/journals/resource/954925492912