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  1H-MRS of the macaque monkey primary visual cortex at 7 T: strategies and pitfalls of shimming at the brain surface

Juchem, C., Logothetis, N., & Pfeuffer, J. (2007). 1H-MRS of the macaque monkey primary visual cortex at 7 T: strategies and pitfalls of shimming at the brain surface. Magnetic Resonance Imaging, 25(6), 902-912.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-D81E-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-D81F-8
Genre: Conference Paper

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 Creators:
Juchem, C1, 2, Author              
Logothetis, NK1, 2, Author              
Pfeuffer, J1, 2, Author              
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: Magnetic resonance spectroscopy (MRS) is ideally suited for physiology–neurochemistry experiments with the living brain and particularly for studies on the primary visual cortex (striate cortex or area V1). Yet, the highly convoluted form of the human V1 has thus far prevented the performance of MRS investigations that are spatially confined within the gray matter of this area. Typically, these studies are compromised by partial volume contaminations originating from white matter tissue, cerebrospinal fluid and other cortical areas. In this study, was exploited the relative flatness of V1 in macaques to enable single-voxel 1H-MRS from a small volume (5×1.6×5 mm3, 40 μl) that was entirely confined within the V1 gray matter of anesthetized monkeys. Linewidths of 13.5±1.9 Hz and 13.0±1.3 Hz for water and creatine, respectively, were achieved with a two-step shimming strategy for voxels at the brain surface. The quality of the obtained results paves the way for further neuroscientific research, including studies on the cortical microcircuits and the dynamic longitudinal changes occurring during cortical reorganization and plasticity.

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 Dates: 2007-07
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1016/j.mri.2007.03.008
 Degree: -

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Title: 5th Workshop of the International School on Magnetic Resonance and Brain Function
Place of Event: Erice, Italy
Start-/End Date: 2007-05-21 - 2007-05-28

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Title: Magnetic Resonance Imaging
Source Genre: Journal
 Creator(s):
Giove, F, Editor
Maraviglia, B, Editor
Gore, J, Editor
Affiliations:
-
Publ. Info: New York : Elsevier
Pages: - Volume / Issue: 25 (6) Sequence Number: - Start / End Page: 902 - 912 Identifier: ISSN: 0730-725X
CoNE: https://pure.mpg.de/cone/journals/resource/954925533026