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  Multi-echo fMRI, resting-state connectivity, and high psychometric schizotypy

Waltmann, M., O'Daly, O., Egerton, A., McMullen, K., Kumari, V., Barker, G. J., et al. (2018). Multi-echo fMRI, resting-state connectivity, and high psychometric schizotypy. NeuroImage: Clinical, 21: 101603. doi:10.1016/j.nicl.2018.11.013.

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 Creators:
Waltmann, Maria1, Author              
O'Daly, Owen2, Author
Egerton, Alice 1, Author
McMullen, Katrina2, Author
Kumari, Veena3, 4, Author
Barker, Gareth J.2, Author
Williams, Steve C. R.2, Author
Modinos, Gemma1, 2, Author
Affiliations:
1Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, United Kingdom, ou_persistent22              
2Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, United Kingdom, ou_persistent22              
3Centre for Cognitive Neuroscience, College of Health and Life Sciences, Brunel University London, United Kingdom, ou_persistent22              
4Department of Psychology, Institute of Psychiatry, Psychology & Neuroscience, King's College London, United Kingdom, ou_persistent22              

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Free keywords: Multi-echo fMRI; Schizotypy; Psychosis; Functional connectivity; Striatum; Resting-state
 Abstract: Disrupted striatal functional connectivity is proposed to play a critical role in the development of psychotic symptoms. Previous resting-state functional magnetic resonance imaging (rs-fMRI) studies typically reported disrupted striatal connectivity in patients with psychosis and in individuals at clinical and genetic high risk of the disorder relative to healthy controls. This has not been widely studied in healthy individuals with subclinical psychotic-like experiences (schizotypy). Here we applied the emerging technology of multi-echo rs-fMRI to examine corticostriatal connectivity in this group, which is thought to drastically maximize physiological noise removal and increase BOLD contrast-to-noise ratio. Multi-echo rs-fMRI data (echo times, 12, 28, 44, 60 ms) were acquired from healthy individuals with low (LS, n = 20) and high (HS, n = 19) positive schizotypy as determined with the Oxford-Liverpool Inventory of Feelings and Experiences (O-LIFE). After preprocessing to ensure optimal contrast and removal of non-BOLD signal components, whole-brain functional connectivity from six striatal seeds was compared between the HS and LS groups. Effects were considered significant at cluster-level p < .05 family-wise error correction. Compared to LS, HS subjects showed lower rs-fMRI connectivity between ventromedial prefrontal regions and ventral striatal regions. Lower connectivity was also observed between the dorsal putamen and the hippocampus, occipital regions, as well as the cerebellum. These results demonstrate that subclinical positive psychotic-like experiences in healthy individuals are associated with striatal hypoconnectivity as detected using multi-echo rs-fMRI. Further application of this approach may aid in characterizing functional connectivity abnormalities across the extended psychosis phenotype.

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Language(s): eng - English
 Dates: 2018-11-162018-08-152018-11-182018-11-20
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.nicl.2018.11.013
PMID: 30503214
PMC: PMC6413302
Other: Epub 2018
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Project name : -
Grant ID : 21200
Funding program : NARSAD Young Investigator Award
Funding organization : Brain and Behavior Research Foundation
Project name : -
Grant ID : 202397/Z/16/Z
Funding program : Sir Henry Dale Fellowship
Funding organization : Wellcome Trust and the Royal Society

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Title: NeuroImage: Clinical
Source Genre: Journal
 Creator(s):
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Publ. Info: Elsevier
Pages: - Volume / Issue: 21 Sequence Number: 101603 Start / End Page: - Identifier: ISSN: 2213-1582
CoNE: https://pure.mpg.de/cone/journals/resource/2213-1582