Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT
  Multi-echo fMRI, resting-state connectivity, and high psychometric schizotypy

Waltmann, M., O'Daly, O., Egerton, A., McMullen, K., Kumari, V., Barker, G. J., et al. (2018). Multi-echo fMRI, resting-state connectivity, and high psychometric schizotypy. NeuroImage: Clinical, 21: 101603. doi:10.1016/j.nicl.2018.11.013.

Item is

Basisdaten

einblenden: ausblenden:
Genre: Zeitschriftenartikel

Dateien

einblenden: Dateien
ausblenden: Dateien
:
Waltmann_2018.pdf (Verlagsversion), 2MB
Name:
Waltmann_2018.pdf
Beschreibung:
-
OA-Status:
Sichtbarkeit:
Öffentlich
MIME-Typ / Prüfsumme:
application/pdf / [MD5]
Technische Metadaten:
Copyright Datum:
-
Copyright Info:
-
Lizenz:
-

Externe Referenzen

einblenden:

Urheber

einblenden:
ausblenden:
 Urheber:
Waltmann, Maria1, Autor           
O'Daly, Owen2, Autor
Egerton, Alice 1, Autor
McMullen, Katrina2, Autor
Kumari, Veena3, 4, Autor
Barker, Gareth J.2, Autor
Williams, Steve C. R.2, Autor
Modinos, Gemma1, 2, Autor
Affiliations:
1Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, United Kingdom, ou_persistent22              
2Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, United Kingdom, ou_persistent22              
3Centre for Cognitive Neuroscience, College of Health and Life Sciences, Brunel University London, United Kingdom, ou_persistent22              
4Department of Psychology, Institute of Psychiatry, Psychology & Neuroscience, King's College London, United Kingdom, ou_persistent22              

Inhalt

einblenden:
ausblenden:
Schlagwörter: Multi-echo fMRI; Schizotypy; Psychosis; Functional connectivity; Striatum; Resting-state
 Zusammenfassung: Disrupted striatal functional connectivity is proposed to play a critical role in the development of psychotic symptoms. Previous resting-state functional magnetic resonance imaging (rs-fMRI) studies typically reported disrupted striatal connectivity in patients with psychosis and in individuals at clinical and genetic high risk of the disorder relative to healthy controls. This has not been widely studied in healthy individuals with subclinical psychotic-like experiences (schizotypy). Here we applied the emerging technology of multi-echo rs-fMRI to examine corticostriatal connectivity in this group, which is thought to drastically maximize physiological noise removal and increase BOLD contrast-to-noise ratio. Multi-echo rs-fMRI data (echo times, 12, 28, 44, 60 ms) were acquired from healthy individuals with low (LS, n = 20) and high (HS, n = 19) positive schizotypy as determined with the Oxford-Liverpool Inventory of Feelings and Experiences (O-LIFE). After preprocessing to ensure optimal contrast and removal of non-BOLD signal components, whole-brain functional connectivity from six striatal seeds was compared between the HS and LS groups. Effects were considered significant at cluster-level p < .05 family-wise error correction. Compared to LS, HS subjects showed lower rs-fMRI connectivity between ventromedial prefrontal regions and ventral striatal regions. Lower connectivity was also observed between the dorsal putamen and the hippocampus, occipital regions, as well as the cerebellum. These results demonstrate that subclinical positive psychotic-like experiences in healthy individuals are associated with striatal hypoconnectivity as detected using multi-echo rs-fMRI. Further application of this approach may aid in characterizing functional connectivity abnormalities across the extended psychosis phenotype.

Details

einblenden:
ausblenden:
Sprache(n): eng - English
 Datum: 2018-11-162018-08-152018-11-182018-11-20
 Publikationsstatus: Online veröffentlicht
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1016/j.nicl.2018.11.013
PMID: 30503214
PMC: PMC6413302
Anderer: Epub 2018
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden: ausblenden:
Projektname : -
Grant ID : 21200
Förderprogramm : NARSAD Young Investigator Award
Förderorganisation : Brain and Behavior Research Foundation
Projektname : -
Grant ID : 202397/Z/16/Z
Förderprogramm : Sir Henry Dale Fellowship
Förderorganisation : Wellcome Trust and the Royal Society

Quelle 1

einblenden:
ausblenden:
Titel: NeuroImage: Clinical
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Elsevier
Seiten: - Band / Heft: 21 Artikelnummer: 101603 Start- / Endseite: - Identifikator: ISSN: 2213-1582
CoNE: https://pure.mpg.de/cone/journals/resource/2213-1582