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  Preparation method of outer core octasaccharide of Helicobacter pylori lipopolysaccharide
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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-E6AE-6 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-E6AF-5
Genre: Patent

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Patent.pdf (Publisher version), 2MB
 
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Patent.pdf
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Restricted (Max Planck Institute of Colloids and Interfaces, Potsdam-Golm; )
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Patent (Publisher version)
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 Creators:
Yin, Jian, Inventor
Hu, Jing, Inventor
Seeberger, Peter H.1, Inventor              
ZOU, Xiaopeng, Inventor
Affiliations:
1Peter H. Seeberger, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_2040285              

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 Abstract: The disclosure discloses a preparation method of outer core octasaccharide of Helicobacter pylori lipopolysaccharide , and belongs to the field of carbohydrate chemistry . The structure of the outer core octasaccharide of Helicobacter pylori is ( a - D - Glc - ( 1 - 3 ) - a - D - Glc - ( 1 - 4 ) - B - D - Gal - ( 1 - 7 ) - D a - D - Hep?a - D - Glc - ( 1 - 6 ) - a - D - Glc - ( 1 - 6 ) - a - D - Glc - ( 1 - 2 ) - D a - D - Hep ] - Linker . The structure consists of three monosac charides : glucose , galactose and heptose . It contains five a - glycosidic bonds of glucose , one ß - glycosidic bond of galactose and two a - glycosidic bonds of heptose . The dis closure prepares the octasaccharide by the synergistic action of remote neighboring group participation effect , solvent effect , temperature effect , additives and leaving groups . The reducing end of the octasaccharide may also be linked with a linker for future attachment to the protein to form a glycoconjugate for immunological studies .

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 Dates: 2017-12-112019-06-13
 Publication Status: Published online
 Pages: -
 Publishing info: United States : US20190177441A1
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