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  Scale-invariant patterning by size-dependent inhibition of Nodal signalling

Almuedo-Castillo, M., Bläßle, A., Mörsdorf, D., Marcon, L., Soh, G., Rogers, K., et al. (2018). Scale-invariant patterning by size-dependent inhibition of Nodal signalling. Nature Cell Biology, 20(9), 1032-1042. doi:10.1038/s41556-018-0155-7.

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 Creators:
Almuedo-Castillo, M1, Author           
Bläßle, A1, Author           
Mörsdorf, D1, Author           
Marcon, L1, Author                 
Soh, GH1, Author           
Rogers, KW1, Author           
Schier, AF, Author
Müller, P1, Author           
Affiliations:
1Müller Group, Friedrich Miescher Laboratory, Max Planck Society, Max-Planck-Ring 9, 72076 Tübingen, DE, ou_3008690              

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 Abstract: Individuals can vary substantially in size, but the proportions of their body plans are often maintained. We generated smaller zebrafish by removing 30% of their cells at the blastula stages and found that these embryos developed into normally patterned individuals. Strikingly, the proportions of all germ layers adjusted to the new embryo size within 2 hours after cell removal. As Nodal-Lefty signalling controls germ-layer patterning, we performed a computational screen for scale-invariant models of this activator-inhibitor system. This analysis predicted that the concentration of the highly diffusive inhibitor Lefty increases in smaller embryos, leading to a decreased Nodal activity range and contracted germ-layer dimensions. In vivo studies confirmed that Lefty concentration increased in smaller embryos, and embryos with reduced Lefty levels or with diffusion-hindered Lefty failed to scale their tissue proportions. These results reveal that size-dependent inhibition of Nodal signalling allows scale-invariant patterning.

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Language(s): eng - English
 Dates: 2018-09
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/s41556-018-0155-7
PMID: 30061678
 Degree: -

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Title: Nature Cell Biology
  Other : 'Nat. Cell Biol.'
Source Genre: Journal
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Publ. Info: London : Springer Nature
Pages: - Volume / Issue: 20 (9) Sequence Number: - Start / End Page: 1032 - 1042 Identifier: ISSN: 1465-7392
CoNE: https://pure.mpg.de/cone/journals/resource/954925625310