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  Recombining your way out of trouble: the genetic architecture of hybrid fitness under environmental stress

Zhang, Z., Bendixsen, D. P., Janzen, T., Nolte, A. W., Greig, D., & Stelkens, R. (2020). Recombining your way out of trouble: the genetic architecture of hybrid fitness under environmental stress. Molecular Biology and Evolution, 37(1), 167-182. doi:10.1093/molbev/msz211.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-53AE-B Version Permalink: http://hdl.handle.net/21.11116/0000-0006-B8A3-2
Genre: Journal Article

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 Creators:
Zhang, Zebin, Author
Bendixsen, Devin P., Author
Janzen, Thijs1, Author              
Nolte, Arne W.1, Author              
Greig, Duncan1, Author              
Stelkens, Rike1, Author              
Affiliations:
1Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_971545              

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Free keywords: Saccharomyces, hybridization, environmental stress, ddRADseq, heterozygosity, epistasis, genome evolution
 Abstract: Hybridization between species is a fundamental evolutionary force that can both promote and delay adaptation. There is a deficit in our understanding of the genetic basis of hybrid fitness, especially in non-domesticated organisms. We also know little about how hybrid fitness changes as a function of environmental stress. Here, we made genetically variable F2 hybrid populations from two divergent Saccharomyces yeast species, exposed populations to ten toxins, and sequenced the most resilient hybrids on low coverage using ddRADseq. We expected to find strong negative epistasis and heterozygote advantage in the hybrid genomes. We investigated three aspects of hybridness: 1) hybridity, 2) interspecific heterozygosity, and 3) epistasis (positive or negative associations between non-homologous chromosomes). Linear mixed effect models revealed strong genotype-by-environment interactions with many chromosomes and chromosomal interactions showing species-biased content depending on the environment. Against our predictions, we found extensive selection against heterozygosity such that homozygous allelic combinations from the same species were strongly overrepresented in an otherwise hybrid genomic background. We also observed multiple cases of positive epistasis between chromosomes from opposite species, confirmed by epistasis- and selection-free simulations, which is surprising given the large divergence of the parental species (~15% genome-wide). Together, these results suggest that stress-resilient hybrid genomes can be assembled from the best features of both parents, without paying high costs of negative epistasis across large evolutionary distances. Our findings illustrate the importance of measuring genetic trait architecture in an environmental context when determining the evolutionary potential of hybrid populations.

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Language(s): eng - English
 Dates: 2019-09-132020-01
 Publication Status: Published in print
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 Identifiers: DOI: 10.1093/molbev/msz211
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Title: Molecular Biology and Evolution
  Other : Mol. Biol. Evol.
Source Genre: Journal
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Publ. Info: Oxford : Oxford University Press
Pages: - Volume / Issue: 37 (1) Sequence Number: - Start / End Page: 167 - 182 Identifier: ISSN: 0737-4038
CoNE: https://pure.mpg.de/cone/journals/resource/954925536119