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  Spatial resolution and imaging encoding fMRI settings for optimal cortical and subcortical motor somatotopy in the human brain

Marquis, R., Muller, S., Lorio, S., Rodriguez-Herreros, B., Melie-Garcia, L., Kherif, F., et al. (2019). Spatial resolution and imaging encoding fMRI settings for optimal cortical and subcortical motor somatotopy in the human brain. Frontiers in Neuroscience, 13: 571. doi:10.3389/fnins.2019.00571.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0003-DD5B-F Version Permalink: https://hdl.handle.net/21.11116/0000-0004-638A-1
Genre: Journal Article

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 Creators:
Marquis, Renaud 1, 2, Author
Muller, Sandrine 3, 4, 5, Author
Lorio, Sara 1, 5, Author
Rodriguez-Herreros, Borja 1, 6, Author
Melie-Garcia, Lester 1, Author
Kherif, Ferath 1, Author
Lutti, Antoine 1, Author
Draganski, Bogdan1, 7, Author           
Affiliations:
1Département des Neurosciences Cliniques, Laboratoire de Recherche en Neuroimagerie (LREN), Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
2Department of Clinical Neurosciences, School of Medicine, University of Geneva, Switzerland, ou_persistent22              
3Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA, ou_persistent22              
4Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA, ou_persistent22              
5UCL Great Ormond Street Institute of Child Health, University College London, United Kingdom, ou_persistent22              
6Sensory-Motor Laboratory (SeMoLa), Jules-Gonin Eye Hospital, University of Lausanne, Switzerland, ou_persistent22              
7Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              

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Free keywords: Functional magnetic resonance imaging; segregation; Image resolution; BOLD sensitivity; Subcortical areas
 Abstract: There is much controversy about the optimal trade-off between blood-oxygen-level-dependent (BOLD) sensitivity and spatial precision in experiments on brain’s topology properties using functional magnetic resonance imaging (fMRI). The sparse empirical evidence and regional specificity of these interactions pose a practical burden for the choice of imaging protocol parameters. Here, we test in a motor somatotopy experiment the impact of fMRI spatial resolution on differentiation between body part representations in cortex and subcortical structures. Motor somatotopy patterns were obtained in a block-design paradigm and visually cued movements of face, upper and lower limbs at 1.5, 2, and 3 mm spatial resolution. The degree of segregation of the body parts’ spatial representations was estimated using a pattern component model. In cortical areas, we observed the same level of segregation between somatotopy maps across all three resolutions. In subcortical areas the degree of effective similarity between spatial representations was significantly impacted by the image resolution. The 1.5 mm 3D EPI and 3 mm 2D EPI protocols led to higher segregation between motor representations compared to the 2 mm 3D EPI protocol. This finding could not be attributed to differential BOLD sensitivity or delineation of functional areas alone and suggests a crucial role of the image encoding scheme – i.e., 2D vs. 3D EPI. Our study contributes to the field by providing empirical evidence about the impact of acquisition protocols for the delineation of somatotopic areas in cortical and sub-cortical brain regions.

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Language(s): eng - English
 Dates: 2018-09-192019-05-202019-06-11
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.3389/fnins.2019.00571
 Degree: -

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Project name : NCCR Synapsy
Grant ID : 32003B_159780
Funding program : -
Funding organization : Swiss National Science Foundation
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Funding organization : Leenaards Foundation
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Funding organization : Foundation Synapsis
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Funding organization : Roger De Spoelberch Foundation
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Funding organization : Partridge Foundations
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Grant ID : GN2214
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Funding organization : Henry Smith Charity and Action Medical Research
Project name : Sinergia project
Grant ID : CRSII5_170873
Funding program : -
Funding organization : Swiss National Science Foundation
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Funding program : -
Funding organization : National Institute for Health Research Biomedical Research Centre

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Title: Frontiers in Neuroscience
  Other : Front Neurosci
Source Genre: Journal
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Publ. Info: Lausanne, Switzerland : Frontiers Research Foundation
Pages: - Volume / Issue: 13 Sequence Number: 571 Start / End Page: - Identifier: ISSN: 1662-4548
ISSN: 1662-453X
CoNE: https://pure.mpg.de/cone/journals/resource/1662-4548