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  A new computational approach to estimate whole-brain effective connectivity from functional and structural MRI, applied to language development

Hahn, G., Skeide, M. A., Mantini, D., Ganzetti, M., Destexhe, A., Friederici, A. D., et al. (2019). A new computational approach to estimate whole-brain effective connectivity from functional and structural MRI, applied to language development. Scientific Reports, 9: 8479. doi:10.1038/s41598-019-44909-6.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-DD7E-8 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-9EAA-B
Genre: Journal Article

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 Creators:
Hahn, Gerald 1, 2, Author
Skeide, Michael A.3, Author              
Mantini, Dante 4, 5, Author
Ganzetti, Marco4, Author
Destexhe, Alain 2, Author
Friederici, Angela D.3, Author              
Deco, Gustavo1, 6, Author              
Affiliations:
1Department of Information and Communication Technologies, Center for Brain and Cognition, University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
2Unit for Neurosciences, Information and Complexity (UNIC), , ou_persistent22              
3Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634551              
4Research Center for Motor Control and Neuroplasticity, Katholieke Universiteit Leuven, Belgium, ou_persistent22              
5Neuroimaging Laboratory, IRCCS: Scientific Institute for Research and Healthcare, Rome, Italy, ou_persistent22              
6Catalan Institution for Research and Advanced Studies (ICREA), University Pompeu Fabra, Barcelona, Spain, ou_persistent22              

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 Abstract: Recently introduced effective connectivity methods allow for the in-vivo investigation of large-scale functional interactions between brain regions. However, dynamic causal modeling, the most widely used technique to date, typically captures only a few predefined regions of interest. In this study, we present an alternative computational approach to infer effective connectivity within the entire connectome and show its performance on a developmental cohort with emerging language capacities. The novel approach provides new opportunities to quantify effective connectivity changes in the human brain.

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Language(s): eng - English
 Dates: 2018-01-252019-03-232019-05-11
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1038/s41598-019-44909-6
PMID: 31186486
PMC: PMC6559954
 Degree: -

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Project name : The Dynamical and Structural Basis of Human Mind Complexity: Segregation and Integration of Information and Processing in the Brain / DYSTRUCTURE
Grant ID : 295129
Funding program : Funding Programme 7
Funding organization : European Commission (EC)
Project name : -
Grant ID : PSI2013-42091
Funding program : Programa Estatal de Investigación Cientifica y Tecnica de Excelencia MINECO
Funding organization : Ministerio de Ciencia, Innovación y Universidades
Project name : Brain-inspired multiscale computation in neuromorphic hybrid systems / BRAINSCALES
Grant ID : 269921
Funding program : Funding Programme 7
Funding organization : European Commission (EC)
Project name : -
Grant ID : 101253/Z/13/Z
Funding program : Sir Henry Dale Fellowship
Funding organization : Wellcome Trust and the Royal Society
Project name : Inter-areal cortical communication: investigating the relationship between hemodynamic and electrophysiological measurements / NEURO-COMM
Grant ID : 334039
Funding program : Funding Programme 7
Funding organization : European Commission (EC)
Project name : -
Grant ID : C16/15/070
Funding program : Special Research Fund
Funding organization : KU Leuven
Project name : -
Grant ID : 12G9417N
Funding program : -
Funding organization : Research Foundation Flanders (FWO)
Project name : [PEGASUS]², giving wings to your career / PEGASUS-2
Grant ID : 665501
Funding program : Horizon 2020
Funding organization : European Commission (EC)
Project name : The Human Brain Project / HBP
Grant ID : 604102
Funding program : Funding Programme 7
Funding organization : European Commission (EC)
Project name : -
Grant ID : -
Funding program : -
Funding organization : Centre national de la recherche scientifique (CNRS)
Project name : -
Grant ID : -
Funding program : -
Funding organization : Fondation Voir et Entendre
Project name : Neural basis of syntax in the developing brain / NEUROSYNTAX
Grant ID : 269505
Funding program : Funding Programme 7
Funding organization : European Commission (EC)

Source 1

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Title: Scientific Reports
  Abbreviation : Sci. Rep.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: London, UK : Nature Publishing Group
Pages: - Volume / Issue: 9 Sequence Number: 8479 Start / End Page: - Identifier: ISSN: 2045-2322
CoNE: https://pure.mpg.de/cone/journals/resource/2045-2322