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  The role of the cerebellum in adaptation: ALE meta‐analyses on sensory feedback error

Johnson, J. F., Belyk, M., Schwartze, M., Pinheiro, A. P., & Kotz, S. A. (2019). The role of the cerebellum in adaptation: ALE meta‐analyses on sensory feedback error. Human Brain Mapping, 40(13), 3966-3981. doi:10.1002/hbm.24681.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-DD91-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-63F5-8
Genre: Journal Article

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 Creators:
Johnson, Joseph F.1, Author
Belyk , Michel 1, 2, Author
Schwartze, Michael 1, Author
Pinheiro , Ana P. 3, Author
Kotz, Sonja A.1, 4, Author              
Affiliations:
1Maastricht University, the Netherlands, ou_persistent22              
2Holland Bloorview Kids Rehabilitation Hospital, Toronto, ON, Canada, ou_persistent22              
3Faculty of Psychology, University of Lisbon, Portugal, ou_persistent22              
4Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              

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Free keywords: Cerebellum; fMRI; Forward model; Meta‐analysis; Prediction; Sensory feedback
 Abstract: It is widely accepted that unexpected sensory consequences of self‐action engage the cerebellum. However, we currently lack consensus on where in the cerebellum, we find fine‐grained differentiation to unexpected sensory feedback. This may result from methodological diversity in task‐based human neuroimaging studies that experimentally alter the quality of self‐generated sensory feedback. We gathered existing studies that manipulated sensory feedback using a variety of methodological approaches and performed activation likelihood estimation (ALE) meta‐analyses. Only half of these studies reported cerebellar activation with considerable variation in spatial location. Consequently, ALE analyses did not reveal significantly increased likelihood of activation in the cerebellum despite the broad scientific consensus of the cerebellum's involvement. In light of the high degree of methodological variability in published studies, we tested for statistical dependence between methodological factors that varied across the published studies. Experiments that elicited an adaptive response to continuously altered sensory feedback more frequently reported activation in the cerebellum than those experiments that did not induce adaptation. These findings may explain the surprisingly low rate of significant cerebellar activation across brain imaging studies investigating unexpected sensory feedback. Furthermore, limitations of functional magnetic resonance imaging to probe the cerebellum could play a role as climbing fiber activity associated with feedback error processing may not be captured by it. We provide methodological recommendations that may guide future studies.

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Language(s): eng - English
 Dates: 2019-05-012019-02-132019-05-092019-06-022019-09
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: PMID: 31155815
DOI: 10.1002/hbm.24681
Other: Epub ahead of print
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Funding organization : Maastricht Brain Imaging Centre
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Grant ID : PTDC/MHC‐PCN/0101/2014
Funding program : -
Funding organization : Fundação para a Ciência e a Tecnologia
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Grant ID : BIAL 238/16
Funding program : -
Funding organization : BIAL Foundation

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Title: Human Brain Mapping
Source Genre: Journal
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Publ. Info: New York : Wiley-Liss
Pages: - Volume / Issue: 40 (13) Sequence Number: - Start / End Page: 3966 - 3981 Identifier: ISSN: 1065-9471
CoNE: https://pure.mpg.de/cone/journals/resource/954925601686