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  Releasing the concept of HLA-allele specific peptide anchors in viral infections: A non-canonical naturally presented human cytomegalovirus-derived HLA-A*24:02 restricted peptide drives exquisite immunogenicity.

Pump, W. C., Schulz, R., Huyton, T., Kunze-Schumacher, H., Martens, J., Ho, G. G. T., et al. (2019). Releasing the concept of HLA-allele specific peptide anchors in viral infections: A non-canonical naturally presented human cytomegalovirus-derived HLA-A*24:02 restricted peptide drives exquisite immunogenicity. HLA: Immune Response Genetics, 94(1), 25-38. doi:10.1111/tan.13537.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-DDC7-4 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-DDCD-E
Genre: Journal Article

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 Creators:
Pump, W. C., Author
Schulz, R., Author
Huyton, T.1, Author              
Kunze-Schumacher, H., Author
Martens, J., Author
Ho, G. G. T., Author
Blasczyk, R., Author
Bade-Doeding, C., Author
Affiliations:
1Department of Cellular Logistics, MPI for Biophysical Chemistry, Max Planck Society, ou_578574              

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Free keywords: antigen presentation; HCMV; HLA class I; peptides; T-cells
 Abstract: T-cell receptors possess the unique ability to survey and respond to their permanently modified ligands, self HLA-I molecules bound to non-self peptides of various origin. This highly specific immune function is impaired following hematopoietic stem cell transplantation (HSCT) for a timespan of several months needed for the maturation of T-cells. Especially, the progression of HCMV disease in immunocompromised patients induces life-threatening situations. Therefore, the need for a new immune system that delivers vital and potent CD8+ T-cells carrying TCRs that recognize even one human cytomegalovirus (HCMV) peptide/HLA molecule and clear the viral infection long term becomes obvious. The transcription and translation of HCMV proteins in the lytic cycle is a precisely regulated cascade of processes, therefore, it is a highly sensitive challenge to adjust the exact time point of HCMV-peptide recruitment over self-peptides. We utilized soluble HLA technology in HCMV-infected fibroblasts and sequenced naturally sHLA-A*24:02 presented HCMV-derived peptides. One peptide of 14 AAs length derived from the IE2 antigen induced the strongest T-cell responses; this peptide can be detected with a low ranking score in general peptide prediction databanks. These results highlight the need for elaborate and HLA-allele specific peptide selection.

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Language(s): eng - English
 Dates: 2019-03-262019-07
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1111/tan.13537
 Degree: -

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Title: HLA: Immune Response Genetics
Source Genre: Journal
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Pages: - Volume / Issue: 94 (1) Sequence Number: - Start / End Page: 25 - 38 Identifier: -