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  Feasibility of functional MRI at ultralow magnetic field via changes in cerebral blood volume

Buckenmaier, K., Pedersen, A., SanGiorgio, P., Scheffler, K., Clarke, J., & Inglis, B. (2019). Feasibility of functional MRI at ultralow magnetic field via changes in cerebral blood volume. Poster presented at 21st ISMAR - 15th EUROMAR Jount Conference (EUROISMAR 2019), Berlin, Germany.

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Buckenmaier, K1, 2, Author              
Pedersen, A, Author
SanGiorgio, P, Author
Scheffler, K1, 2, Author              
Clarke, J, Author
Inglis, B, Author
Affiliations:
1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: We investigate the feasibility of performing functional MRI (fMRI) at ultralow field (ULF) with a Superconducting Quantum Interference Device (SQUID), as used for detecting magnetoencephalography (MEG) signals from the human head. While there is negligible magnetic susceptibility variation to produce blood oxygenation level-dependent (BOLD) contrast at ULF, changes in cerebral blood volume (CBV) may be a sensitive mechanism for fMRI given the five-fold spread in spin-lattice relaxation time (T1) values across the constituents of the human brain. We undertook simulations of functional signal strength for a simplified brain model involving activation of a primary cortical region in a manner consistent with a blocked task experiment. Our simulations involve measured values of T1 at ULF (130 μT) and experimental parameters for the performance of an ULFMRI scanner with a noise level of 0.1 fT/Hz-1/2 and a prepolarizing field of 200 mT. Under ideal experimental conditions we predict a functional signal-to-noise ratio of between 3.1 and 7.1 for an imaging time of 30 min, or between 1.5 and 3.5 for a blocked task experiment lasting 7.5 min. Our simulations suggest it may be feasible but challenging to perform fMRI using a ULFMRI system designed to perform MRI and MEG in situ.

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 Dates: 2019-08
 Publication Status: Published online
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Title: 21st ISMAR - 15th EUROMAR Jount Conference (EUROISMAR 2019)
Place of Event: Berlin, Germany
Start-/End Date: 2019-08-25 - 2019-08-30

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Title: EUROISMAR 2019 Joint Conference
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: P552 Start / End Page: 758 Identifier: -