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  Multiscale analyses reveal native-like lamellar bone repair and near perfect bone-contact with porous strontium-loaded bioactive glass

Autefage, H., Allen, F., Tang, H., Kallepitis, C., Gentleman, E., Reznikov, N., et al. (2019). Multiscale analyses reveal native-like lamellar bone repair and near perfect bone-contact with porous strontium-loaded bioactive glass. Biomaterials, 209, 152-162. doi:10.1016/j.biomaterials.2019.03.035.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-E6F7-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-C313-A
Genre: Journal Article

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 Creators:
Autefage, H., Author
Allen, F., Author
Tang, H.M., Author
Kallepitis, C., Author
Gentleman, E., Author
Reznikov, N., Author
Nitiputri, K., Author
Nommeots-Nomm, A., Author
O'Donnell, M.D., Author
Lange, Claudia1, Author              
Seidt, Britta2, Author              
Kim, T.B., Author
Solanki, A.K., Author
Tallia, F., Author
Young, G., Author
Lee, P.D., Author
Pierce, B.F., Author
Wagermaier, Wolfgang2, Author              
Fratzl, Peter3, Author              
Goodship, A., Author
Jones, J.R., AuthorBlunn, G., AuthorStevens, M.M., Author more..
Affiliations:
1Biomaterialien, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863285              
2Wolfgang Wagermaier, Biomaterialien, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863296              
3Peter Fratzl, Biomaterialien, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863294              

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Free keywords: 3D porous bioactive glass, Strontium-releasing materials, Raman spectroscopy, Critical-sized bone repair, FIB-SEM, SAXS
 Abstract: The efficient healing of critical-sized bone defects using synthetic biomaterial-based strategies is promising but remains challenging as it requires the development of biomaterials that combine a 3D porous architecture and a robust biological activity. Bioactive glasses (BGs) are attractive candidates as they stimulate a biological response that favors osteogenesis and vascularization, but amorphous 3D porous BGs are difficult to produce because conventional compositions crystallize during processing. Here, we rationally designed a porous, strontium-releasing, bioactive glass-based scaffold (pSrBG) whose composition was tailored to deliver strontium and whose properties were optimized to retain an amorphous phase, induce tissue infiltration and encourage bone formation. The hypothesis was that it would allow the repair of a critical-sized defect in an ovine model with newly-formed bone exhibiting physiological matrix composition and structural architecture. Histological and histomorphometric analyses combined with indentation testing showed pSrBG encouraged near perfect bone-to-material contact and the formation of well-organized lamellar bone. Analysis of bone quality by a combination of Raman spectral imaging, small-angle X-ray scattering, X-ray fluorescence and focused ion beamscanning electron microscopy demonstrated that the repaired tissue was akin to that of normal, healthy bone, and incorporated small amounts of strontium in the newly formed bone mineral. These data show the potential of pSrBG to induce an efficient repair of critical-sized bone defects and establish the importance of thorough multi-scale characterization in assessing biomaterial outcomes in large animal models.

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Language(s): eng - English
 Dates: 2019-03-292019
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1016/j.biomaterials.2019.03.035
PMID: 0565
 Degree: -

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Title: Biomaterials
Source Genre: Journal
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Publ. Info: Guildford, England : Elsevier
Pages: - Volume / Issue: 209 Sequence Number: - Start / End Page: 152 - 162 Identifier: ISSN: 0142-9612