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  Metabolome signature of autism in the human prefrontal cortex

Kurochkin, I., Khrameeva, E., Tkachev, A., Stepanova, V., Vanyushkina, A., Stekolshchikova, E., et al. (2019). Metabolome signature of autism in the human prefrontal cortex. Communications Biology, 2(1): 234. doi:10.1038/s42003-019-0485-4.

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Kurochkin, Ilia1, Author
Khrameeva, Ekaterina1, Author
Tkachev, Anna1, Author
Stepanova, Vita1, Author
Vanyushkina, Anna1, Author
Stekolshchikova, Elena1, Author
Li, Qian1, Author
Zubkov, Dmitry1, Author
Shichkova, Polina1, Author
Halene, Tobias1, Author
Willmitzer, L.2, Author              
Giavalisco, Patrick1, Author
Akbarian, Schahram1, Author
Khaitovich, Philipp1, Author
Affiliations:
1external, ou_persistent22              
2Small Molecules, Department Willmitzer, Max Planck Institute of Molecular Plant Physiology, Max Planck Society, ou_1753340              

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 Abstract: Autism spectrum disorder (ASD) is a common neurodevelopmental disorder with yet incompletely uncovered molecular determinants. Alterations in the abundance of low molecular weight compounds (metabolites) in ASD could add to our understanding of the disease. Indeed, such alterations take place in the urine, plasma and cerebellum of ASD individuals. In this work, we investigated mass-spectrometric signal intensities of 1,366 metabolites in the prefrontal cortex grey matter of 32 ASD and 40 control individuals. 15% of these metabolites showed significantly different intensities in ASD and clustered in 16 metabolic pathways. Of them, ten pathways were altered in urine and blood of ASD individuals (Fisher test, p < 0.05), opening an opportunity for the design of new diagnostic instruments. Furthermore, metabolic measurements conducted in 40 chimpanzees and 40 macaques showed an excess of metabolite intensity differences unique to humans, supporting the hypothesized disruption of evolutionary novel cortical mechanisms in ASD.

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Language(s): eng - English
 Dates: 2019
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1038/s42003-019-0485-4
Other: Kurochkin2019
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Title: Communications Biology
Source Genre: Journal
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Publ. Info: London : Springer Nature
Pages: - Volume / Issue: 2 (1) Sequence Number: 234 Start / End Page: - Identifier: ISSN: 2399-3642
CoNE: https://pure.mpg.de/cone/journals/resource/2399-3642