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  Metabolome signature of autism in the human prefrontal cortex

Kurochkin, I., Khrameeva, E., Tkachev, A., Stepanova, V., Vanyushkina, A., Stekolshchikova, E., et al. (2019). Metabolome signature of autism in the human prefrontal cortex. Communications Biology, 2(1): 234. doi:10.1038/s42003-019-0485-4.

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Kurochkin, Ilia1, Autor
Khrameeva, Ekaterina1, Autor
Tkachev, Anna1, Autor
Stepanova, Vita1, Autor
Vanyushkina, Anna1, Autor
Stekolshchikova, Elena1, Autor
Li, Qian1, Autor
Zubkov, Dmitry1, Autor
Shichkova, Polina1, Autor
Halene, Tobias1, Autor
Willmitzer, L.2, Autor           
Giavalisco, Patrick1, Autor
Akbarian, Schahram1, Autor
Khaitovich, Philipp1, Autor
Affiliations:
1external, ou_persistent22              
2Small Molecules, Department Willmitzer, Max Planck Institute of Molecular Plant Physiology, Max Planck Society, ou_1753340              

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 Zusammenfassung: Autism spectrum disorder (ASD) is a common neurodevelopmental disorder with yet incompletely uncovered molecular determinants. Alterations in the abundance of low molecular weight compounds (metabolites) in ASD could add to our understanding of the disease. Indeed, such alterations take place in the urine, plasma and cerebellum of ASD individuals. In this work, we investigated mass-spectrometric signal intensities of 1,366 metabolites in the prefrontal cortex grey matter of 32 ASD and 40 control individuals. 15% of these metabolites showed significantly different intensities in ASD and clustered in 16 metabolic pathways. Of them, ten pathways were altered in urine and blood of ASD individuals (Fisher test, p < 0.05), opening an opportunity for the design of new diagnostic instruments. Furthermore, metabolic measurements conducted in 40 chimpanzees and 40 macaques showed an excess of metabolite intensity differences unique to humans, supporting the hypothesized disruption of evolutionary novel cortical mechanisms in ASD.

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Sprache(n): eng - English
 Datum: 2019
 Publikationsstatus: Erschienen
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 Ort, Verlag, Ausgabe: -
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 Identifikatoren: DOI: 10.1038/s42003-019-0485-4
Anderer: Kurochkin2019
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Titel: Communications Biology
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: London : Springer Nature
Seiten: - Band / Heft: 2 (1) Artikelnummer: 234 Start- / Endseite: - Identifikator: ISSN: 2399-3642
CoNE: https://pure.mpg.de/cone/journals/resource/2399-3642