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  Evidence of Skeletal Fluorosis at the Ray Site, Illinois, USA: a pathological assessment and discussion of environmental factors

Nelson, E. A., Halling, C. L., & Buikstra, J. E. (2019). Evidence of Skeletal Fluorosis at the Ray Site, Illinois, USA: a pathological assessment and discussion of environmental factors. International Journey of Paleopathology, 26, 48-60. doi:10.1016/j.ijpp.2019.05.003.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-E794-1 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-E795-0
Genre: Journal Article

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 Creators:
Nelson, Elizabeth A.1, Author              
Halling, Christine L., Author
Buikstra, Jane E., Author
Affiliations:
1Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2074310              

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Free keywords: Metabolic Bone Disease, Fluoride toxicity, North America, Differential Diagnosis
 Abstract: Objective:: To carefully assess skeletal lesions in close environment context in order to evaluate whether skeletal fluorosis was present in individuals living in the prehistoric Midwest, USA. Materials:: Skeletal remains from minimally 117 individuals recovered from the Ray Site, located in western Illinois (USA) and dated to the Middle/early Late Woodland periods (50 BC-AD 400). Methods:: Macroscopic evaluation of all recovered skeletal elements. Results:: Eight individuals display a constellation of abnormal bony changes, including osteosclerosis, a high frequency of fractures, and dental abnormalities. Conclusions:: The osteosclerotic changes along with the naturally high fluoride content of west central Illinois soil and water suggests the presence of skeletal fluorosis. Significance:: This is the first report of skeletal fluorosis from archaeologically recovered human remains from North America. Limitations:: The ambiguous nature of the skeletal changes associated with fluorosis, especially in the less severe stages of the disease, renders determination of the etiology difficult. Suggestions for Further Research:: The continuation of paleopathological investigations of fluoride toxicity within archaeological communities recovered from this region with emphasis on the incorporation of biomedical and environmental data. Furthermore, complementary analyses of the chemical composition and the histological presentation of the skeletons could provide support for this diagnosis. © 2019 Elsevier Inc.

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Language(s): eng - English
 Dates: 2019-072019-09
 Publication Status: Published in print
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 Identifiers: DOI: 10.1016/j.ijpp.2019.05.003
Other: shh2274
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Title: International Journey of Paleopathology
Source Genre: Journal
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Publ. Info: Elsevier
Pages: - Volume / Issue: 26 Sequence Number: - Start / End Page: 48 - 60 Identifier: ISSN: 1879-9817
CoNE: https://pure.mpg.de/cone/journals/resource/1879-9817