English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Ancient Yersinia pestis genomes from across Western Europe reveal early diversification during the First Pandemic (541–750)

Keller, M., Spyrou, M. A., Scheib, C. L., Neumann, G., Kröpelin, A., Haas-Gebhard, B., et al. (2019). Ancient Yersinia pestis genomes from across Western Europe reveal early diversification during the First Pandemic (541–750). Proceedings of the National Academy of Sciences of the United States of America, 116(25), 12363-12372. doi:10.1073/pnas.1820447116.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0003-EA03-2 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-EA04-1
Genre: Journal Article

Files

show Files
hide Files
:
shh2277.pdf (Publisher version), 2MB
Name:
shh2277.pdf
Description:
OA
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-

Locators

show

Creators

show
hide
 Creators:
Keller, Marcel1, Author              
Spyrou, Maria A.1, Author              
Scheib, Christiana L., Author
Neumann, Gunnar1, Author              
Kröpelin, Andreas1, Author              
Haas-Gebhard, Brigitte, Author
Päffgen, Bernd, Author
Haberstroh, Jochen, Author
Lacomba, Albert Ribera, Author
Raynaud, Claude, Author
Cessford, Craig, Author
Durand, Raphaël, Author
Stadler, Peter, Author
Nägele, Kathrin1, Author              
Bates, Jessica S., Author
Trautmann, Bernd, Author
Inskip, Sarah A., Author
Peters, Joris, Author
Robb, John E., Author
Kivisild, Toomas, Author
Castex, Dominique, AuthorMcCormick, Michael, AuthorBos, Kirsten I.2, Author              Harbeck, Michaela, AuthorHerbig, Alexander1, Author              Krause, Johannes3, Author               more..
Affiliations:
1Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2074310              
2CoDisEASe, Max Planck Institute for the Science of Human History, Max Planck Society, ou_3033585              
3MHAAM, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2541699              

Content

show
hide
Free keywords: Ancient DNA, Anglo-Saxons, Bacterial evolution, Justinianic Plague, Merovingians
 Abstract: The first historically documented pandemic caused by Yersinia pestis began as the Justinianic Plague in 541 within the Roman Empire and continued as the so-called First Pandemic until 750. Although paleogenomic studies have previously identified the causative agent as Y. pestis, little is known about the bacterium’s spread, diversity, and genetic history over the course of the pandemic. To elucidate the microevolution of the bacterium during this time period, we screened human remains from 21 sites in Austria, Britain, Germany, France, and Spain for Y. pestis DNA and reconstructed eight genomes. We present a methodological approach assessing single-nucleotide polymorphisms (SNPs) in ancient bacterial genomes, facilitating qualitative analyses of low coverage genomes from a metagenomic background. Phylogenetic analysis on the eight reconstructed genomes reveals the existence of previously undocumented Y. pestis diversity during the sixth to eighth centuries, and provides evidence for the presence of multiple distinct Y. pestis strains in Europe. We offer genetic evidence for the presence of the Justinianic Plague in the British Isles, previously only hypothesized from ambiguous documentary accounts, as well as the parallel occurrence of multiple derived strains in central and southern France, Spain, and southern Germany. Four of the reported strains form a polytomy similar to others seen across the Y. pestis phylogeny, associated with the Second and Third Pandemics. We identified a deletion of a 45-kb genomic region in the most recent First Pandemic strains affecting two virulence factors, intriguingly overlapping with a deletion found in 17th- to 18th-century genomes of the Second Pandemic. © 2019 National Academy of Sciences. All rights reserved.

Details

show
hide
Language(s):
 Dates: 2019-06-18
 Publication Status: Published online
 Pages: 10
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1073/pnas.1820447116
Other: shh2277
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Proceedings of the National Academy of Sciences of the United States of America
  Other : Proc. Acad. Sci. USA
  Other : Proc. Acad. Sci. U.S.A.
  Other : Proceedings of the National Academy of Sciences of the USA
  Abbreviation : PNAS
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Washington, D.C. : National Academy of Sciences
Pages: - Volume / Issue: 116 (25) Sequence Number: - Start / End Page: 12363 - 12372 Identifier: ISSN: 0027-8424
CoNE: https://pure.mpg.de/cone/journals/resource/954925427230