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  Mucispirillum schaedleri antagonizes salmonella virulence to protect mice against Colitis

Herp, S., Brugiroux, S., Garzetti, D., Ring, D., Jochum, L., Beutler, M., et al. (2019). Mucispirillum schaedleri antagonizes salmonella virulence to protect mice against Colitis. Cell Host & Microbe, 25(5), 681-694.e8. doi:10.1016/j.chom.2019.03.004.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-F001-C Version Permalink: http://hdl.handle.net/21.11116/0000-0003-F003-A
Genre: Journal Article

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 Creators:
Herp, S., Author
Brugiroux, S., Author
Garzetti, D., Author
Ring, D., Author
Jochum, L.M., Author
Beutler, M., Author
Eberl, C., Author
Hussain, S., Author
Walter, S., Author
Gerlach, R.G., Author
Ruscheweyh, H.J., Author
Huson, D., Author
Sellin, M.E., Author
Slack, E., Author
Hanson, B., Author
Loy, A., Author
Baines, J. F.1, Author              
Rausch, P., Author
Basic, M., Author
Bleich, A., Author
Berry, D., AuthorStecher, B., Author more..
Affiliations:
1Guest Group Evolutionary Genomics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445638              

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Free keywords: streptomycin; virulence factor, animal cell; animal experiment; animal model; Article; bacterial virulence; colitis; controlled study; correlation analysis; gene expression; gnotobiotics; intestine flora; mouse; Mucispirillum schaedleri; nonhuman; priority journal; Salmonella enterica serovar Typhimurium; spiral and curved bacteria
 Abstract: The microbiota and the gastrointestinal mucus layer play a pivotal role in protection against non-typhoidal Salmonella enterica serovar Typhimurium (S. Tm) colitis. Here, we analyzed the course of Salmonella colitis in mice lacking a functional mucus layer in the gut. Unexpectedly, in contrast to mucus-proficient littermates, genetically deficient mice were protected against Salmonella-induced gut inflammation in the streptomycin colitis model. This correlated with microbiota alterations and enrichment of the bacterial phylum Deferribacteres. Using gnotobiotic mice associated with defined bacterial consortia, we causally linked Mucispirillum schaedleri, currently the sole known representative of Deferribacteres present in the mammalian microbiota, to host protection against S. Tm colitis. Inhibition by M. schaedleri involves interference with S. Tm invasion gene expression, partly by competing for anaerobic electron acceptors. In conclusion, this study establishes M. schaedleri, a core member of the murine gut microbiota, as a key antagonist of S. Tm virulence in the gut. Herp et al. find that Mucispirillum schaedleri, a low abundant member of the mammalian intestinal microbiota, metabolically competes with Salmonella enterica serovar Typhimurium, thereby interfering with virulence factor expression and subsequent tissue invasion by Salmonella. These data provide a mechanism by which members of the microbiota can antagonize invading pathogens. © 2019 Elsevier Inc.

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Language(s): eng - English
 Dates: 2019-01-102018-10-222019-03-052019-05-082019
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1016/j.chom.2019.03.004
 Degree: -

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Title: Cell Host & Microbe
Source Genre: Journal
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Publ. Info: Cambridge, MA 02139 : Elsevier Inc.
Pages: - Volume / Issue: 25 (5) Sequence Number: - Start / End Page: 681 - 694.e8 Identifier: ISSN: 1931-3128
CoNE: https://pure.mpg.de/cone/journals/resource/1931-3128