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  Acute psychosocial stress alters thalamic network centrality

Reinelt, J., Uhlig, M., Mueller, K., Lauckner, M., Kumral, D., Schaare, H. L., et al. (2019). Acute psychosocial stress alters thalamic network centrality. NeuroImage, 199, 680-690. doi:10.1016/j.neuroimage.2019.06.005.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-ED3E-E Version Permalink: http://hdl.handle.net/21.11116/0000-0004-CA22-2
Genre: Journal Article

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 Creators:
Reinelt, Janis1, Author              
Uhlig, Marie1, 2, Author              
Mueller, Karsten3, Author              
Lauckner, Mark1, 4, Author              
Kumral, Deniz1, 5, Author              
Schaare, Herma Lina1, 2, Author              
Baczkowski, Blazej1, 2, 6, Author              
Babayan, Anahit1, Author              
Erbey, Miray1, 5, 7, Author              
Röbbig, Josefin1, 8, 9, Author              
Reiter, Andrea1, Author              
Bae, Yoon-Ju10, Author
Kratzsch, Jürgen10, Author
Thiery, Joachim10, Author
Hendler, Talma11, Author
Villringer, Arno1, 5, Author              
Gaebler, Michael1, 5, Author              
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2International Max Planck Research School on Neuroscience of Communication: Function, Structure, and Plasticity, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2616696              
3Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
4Charité University Medicine Berlin, Germany, ou_persistent22              
5MindBrainBody Institute, Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              
6Institute of Psychology, University of Leipzig, Germany, ou_persistent22              
7Max Planck Institute for Human Development, Berlin, Germany, ou_persistent22              
8Lifespan Developmental Neuroscience, Department of Biological Psychology, Faculty of Psychology, TU Dresden, Germany, ou_persistent22              
9Max Planck UCL Centre for Computational Psychiatry and Ageing Research, London, United Kingdom, ou_persistent22              
10Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (ILM), University of Leipzig, Germany, ou_persistent22              
11Sagol School of Neuroscience, Tel-Aviv University, Israel, ou_persistent22              

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Free keywords: Resting-state fMRI; Eigenvector centrality mapping; Stress; Cortisol; Thalamus; TSST
 Abstract: Acute stress triggers a broad psychophysiological response that is adaptive if rapidly activated and terminated. While the brain controls the stress response, it is strongly affected by it. Previous research of stress effects on brain activation and connectivity has mainly focused on pre-defined brain regions or networks, potentially missing changes in the rest of the brain. We here investigated how both stress reactivity and stress recovery are reflected in whole-brain network topology and how changes in functional connectivity relate to other stress measures. Healthy young males (n = 67) completed the Trier Social Stress Test or a control task. From 60 min before until 105 min after stress onset, blocks of resting-state fMRI were acquired. Subjective, autonomic, and endocrine measures of the stress response were assessed throughout the experiment. Whole-brain network topology was quantified using Eigenvector centrality (EC) mapping, which detects central hubs of a network. Stress influenced subjective affect, autonomic activity, and endocrine measures. EC differences between groups as well as before and after stress exposure were found in the thalamus, due to widespread connectivity changes in the brain. Stress-driven EC increases in the thalamus were significantly correlated with subjective stress ratings and showed non-significant trends for a correlation with heart rate variability and saliva cortisol. Furthermore, increases in thalamic EC and in saliva cortisol persisted until 105 min after stress onset. We conclude that thalamic areas are central for information processing after stress exposure and may provide an interface for the stress response in the rest of the body and in the mind.

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Language(s): eng - English
 Dates: 2019-05-292018-12-182019-06-032019-06-052019-10-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.neuroimage.2019.06.005
Other: Epub ahead of print
PMID: 31173902
 Degree: -

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Project name : -
Grant ID : 13GW0206B
Funding program : -
Funding organization : German Federal Ministry of Education and Research (BMBF)

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Title: NeuroImage
Source Genre: Journal
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Affiliations:
Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 199 Sequence Number: - Start / End Page: 680 - 690 Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166