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  Molecular Engineering of the TGF-β Signaling Pathway

Zi, Z. (2019). Molecular Engineering of the TGF-β Signaling Pathway. Journal of Molecular Biology (London), 431(15), 2644-2654. doi:10.1016/j.jmb.2019.05.022.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-F2A7-F Version Permalink: http://hdl.handle.net/21.11116/0000-0003-F2A8-E
Genre: Journal Article

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Zi_JMB_2019.pdf (Publisher version), 831KB
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Zi_JMB_2019.pdf
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© 2019 Elsevier Ltd
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 Creators:
Zi, Zhike1, Author              
Affiliations:
1Cell Signaling Dynamics (Zhike Zi), Independent Junior Research Groups (OWL), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_2117284              

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Free keywords: Smad; TGF-beta; protein engineering; synthetic biology
 Abstract: Transforming growth factor beta (TGF-β) is an important growth factor that plays essential roles in regulating tissue development and homeostasis. Dysfunction of TGF-β signaling is a hallmark of many human diseases. Therefore, targeting TGF-β signaling presents broad therapeutic potential. Since the discovery of the TGF-β ligand, a collection of engineered signaling proteins have been developed to probe and manipulate TGF-β signaling responses. In this review, we highlight recent progress in the engineering of TGF-β signaling for different applications and discuss how molecular engineering approaches can advance our understanding of this important pathway. In addition, we provide a future outlook on the opportunities and challenges in the engineering of the TGF-β signaling pathway from a quantitative perspective.

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Language(s): eng - English
 Dates: 2019-05-212019-07-12
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1016/j.jmb.2019.05.022
 Degree: -

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Title: Journal of Molecular Biology (London)
  Other : J Mol Biol
Source Genre: Journal
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Publ. Info: London : Academic Press
Pages: 11 Volume / Issue: 431 (15) Sequence Number: - Start / End Page: 2644 - 2654 Identifier: ISSN: 0022-2836
CoNE: https://pure.mpg.de/cone/journals/resource/954922646042