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  Width and neurophysiologic properties of tissue bridges predict recovery after cervical injury

Vallotton, K., Huber, E., Sutter, R., Curt, A., Hupp, M., & Freund, P. (2019). Width and neurophysiologic properties of tissue bridges predict recovery after cervical injury. Neurology, 92(24), e2793-e2802. doi:10.1212/WNL.0000000000007642.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-FC8A-6 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-6447-C
Genre: Journal Article

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 Creators:
Vallotton, Kevin1, 2, Author
Huber, Eveline1, 2, Author
Sutter, Reto2, 3, Author
Curt, Armin1, 2, Author
Hupp, Markus1, 2, Author
Freund, Patrick1, 2, 4, 5, 6, Author              
Affiliations:
1Balgrist Spinal Cord Injury Center, Balgrist University Hospital, Zurich, Switzerland, ou_persistent22              
2University of Zurich, Switzerland, ou_persistent22              
3Department of Radiology, Balgrist University Hospital, Zurich, Switzerland, ou_persistent22              
4Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, United Kingdom, ou_persistent22              
5Department of Brain Repair & Rehabilitation, University College London, United Kingdom, ou_persistent22              
6Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              

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Free keywords: All Rehabilitation; Plasticity; MRI; Spinal cord trauma
 Abstract: Objective To assess whether preserved dorsal and ventral midsagittal tissue bridges after traumatic cervical spinal cord injury (SCI) encode tract-specific electrophysiologic properties and are predictive of appropriate recovery. Methods In this longitudinal study, we retrospectively assessed MRI scans at 1 month after SCI that provided data on width and location (dorsal vs ventral) of midsagittal tissue bridges in 28 tetraplegic patients. Regression analysis assessed associations between midsagittal tissue bridges and motor- and sensory-specific electrophysiologic recordings and appropriate outcome measures at 12 months after SCI. Results Greater width of dorsal midsagittal tissue bridges at 1 month after SCI identified patients who were classified as being sensory incomplete at 12 months after SCI (p = 0.025), had shorter sensory evoked potential (SEP) latencies (r = −0.57, p = 0.016), and had greater SEP amplitudes (r = 0.61, p = 0.001). Greater width of dorsal tissue bridges predicted better light-touch score at 12 months (r = 0.40, p = 0.045) independently of baseline clinical score and ventral tissue bridges. Greater width of ventral midsagittal tissue bridges at 1 month identified patients who were classified as being motor incomplete at 12 months (p = 0.002), revealed shorter motor evoked potential (MEP) latencies (r = −0.54, p = 0.044), and had greater ratios of MEP amplitude to compound muscle action potential amplitude (r = 0.56, p = 0.005). Greater width of ventral tissue bridges predicted better lower extremity motor scores at 12 months (r = 0.41, p = 0.035) independently of baseline clinical score and dorsal tissue bridges. Conclusion Midsagittal tissue bridges, detectable early after SCI, underwrite tract-specific electrophysiologic communication and are predictors of appropriate sensorimotor recovery. Neuroimaging biomarkers of midsagittal tissue bridges may be integrated into the diagnostic workup, prediction of recovery, and patients' stratification in clinical trials.

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Language(s): eng - English
 Dates: 2018-06-122019-02-072019-05-152019-06-11
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1212/WNL.0000000000007642
Other: Epub 2019
PMID: 31092621
 Degree: -

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Project name : -
Grant ID : WFL-CH-007/14
Funding program : -
Funding organization : Wings for Life, Austria
Project name : -
Grant ID : IRP- P158
Funding program : -
Funding organization : International Foundation for Research in Paraplegia
Project name : Antibodies against Nogo-A to enhance plasticity, regeneration and functional recovery after acute spinal cord injury, a multicenter European clinical proof of concept trial / NISCI
Grant ID : 681094
Funding program : Horizon 2020
Funding organization : European Commission (EC)
Project name : -
Grant ID : PCEFP3_181362/1
Funding program : SNF Eccellenza Professorial Fellowship grant
Funding organization : Swiss National Science Foundation

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Title: Neurology
Source Genre: Journal
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Publ. Info: Cleveland, Ohio [etc.] : Advanstar Communications [etc.]
Pages: - Volume / Issue: 92 (24) Sequence Number: - Start / End Page: e2793 - e2802 Identifier: ISSN: 0028-3878
CoNE: https://pure.mpg.de/cone/journals/resource/954925246073