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  Microbial differences between dental plaque and historic dental calculus are related to oral biofilm maturation stage

Velsko, I. M., Fellows Yates, J. A., Aron, F., Hagan, R., Frantz, L. A. F., Loe, L., et al. (2019). Microbial differences between dental plaque and historic dental calculus are related to oral biofilm maturation stage. Microbiome, 7(1): 102. doi:10.1186/s40168-019-0717-3.

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Supplementary Materials and Methods and Supplementary Figures (Ergänzendes Material)
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Supplemental Tables S1-S7. (Ergänzendes Material)
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 Urheber:
Velsko, Irina M.1, Autor           
Fellows Yates, James A.1, Autor           
Aron, Franziska2, Autor           
Hagan, Richard1, Autor           
Frantz, Laurent A. F., Autor
Loe, Louise, Autor
Martinez, Juan Bautista Rodriguez, Autor
Chaves, Eros, Autor
Gosden, Chris, Autor
Larson, Greger, Autor
Warinner, Christina G.1, Autor           
Affiliations:
1Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2074310              
2PALEoRIDER, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2541702              

Inhalt

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Schlagwörter: Ancient dental calculus, Oral microbiome, Metagenomics, Metaproteomics, Periodontal disease
 Zusammenfassung: Dental calculus, calcified oral plaque biofilm, contains microbial and host biomolecules that can be used to study historic microbiome communities and host responses. Dental calculus does not typically accumulate as much today as historically, and clinical oral microbiome research studies focus primarily on living dental plaque biofilm. However, plaque and calculus reflect different conditions of the oral biofilm, and the differences in microbial characteristics between the sample types have not yet been systematically explored. Here, we compare the microbial profiles of modern dental plaque, modern dental calculus, and historic dental calculus to establish expected differences between these substrates.

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Sprache(n): eng - English
 Datum: 2019-07-06
 Publikationsstatus: Online veröffentlicht
 Seiten: 20
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: - Background
- Results
-- Authentication of a preserved oral biofilm in calculus samples
-- Dental calculus and plaque biofilm communities are distinct
-- Health-associated communities of dental plaque and calculus are distinct
-- Signatures of health and of disease are shared in modern and historic calculus samples
-- Microbial community differences between health and disease in calculus are poorly resolved
-- Absence of caries-specific microbial profiles in dental calculus
-- Microbial co-exclusion patterns in plaque and calculus reflect biofilm maturity
-- Microbial complexes in plaque and calculus
-- Functional prediction in calculus is poorly predictive of health status
-- Proteomic profiles of historic healthy site calculus
-- Correlations between taxonomic, proteomic, and metabolomic profiles
- Discussion
- Conclusions
- Materials and methods
--Historic and modern calculus sample collection DNA extraction
-- DNA library construction and high-throughput sequencing
-- DNA sequence processing
-- Genetic assessment of historic calculus sample preservation
-- Genetic microbial taxonomic profiling
-- Principal component analysis
-- Assessment of differentially abundant taxa
-- Sparse partial least squares-discriminant analysis
-- Assessment of microbial co-exclusion patterns
-- Gene functional categorization with SEED
-- Proteomics
-- Metabolomics
-- Regularized canonical correlation analysis

 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1186/s40168-019-0717-3
Anderer: shh2283
 Art des Abschluß: -

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Titel: Microbiome
Genre der Quelle: Zeitschrift
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Affiliations:
Ort, Verlag, Ausgabe: United Kingdom : BioMed Central
Seiten: - Band / Heft: 7 (1) Artikelnummer: 102 Start- / Endseite: - Identifikator: Anderer: 2049-2618
CoNE: https://pure.mpg.de/cone/journals/resource/2049-2618