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  Neuronal stability in medial frontal cortex sets individual variability in decision-making

Kurikawa, T., Haga, T., Handa, T., Harukuni, R., & Fukai, T. (2018). Neuronal stability in medial frontal cortex sets individual variability in decision-making. Nature Neuroscience, 21(12), 1764-1773. doi:10.1038/s41593-018-0263-5.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0004-40E4-2 Version Permalink: https://hdl.handle.net/21.11116/0000-0004-40E8-E
Genre: Journal Article

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https://www.nature.com/articles/s41593-018-0263-5 (Abstract)
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Kurikawa, Tomoki1, Author
Haga, Tatsuya1, Author
Handa, Takashi1, Author
Harukuni, Rie1, Author
Fukai, Tomoki1, Author
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1External Organizations, ou_persistent22              

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 Abstract: In the brain, decision making is instantiated in dedicated neural circuits. However, there is considerable individual variability in decision-making behavior, particularly under uncertainty. The origins of decision variability within these conserved neural circuits are not known. Here we demonstrate in the rat medial frontal cortex (MFC) that individual variability is a consequence of altered stability in neuronal populations. In a sensory-guided choice task, rats trained on familiar stimuli were exposed to unfamiliar stimuli, resulting in variable choice responses across individuals. We created a recurrent network model to examine the source of variability in MFC neurons, and found that the landscape of neural population trajectories explained choice variability across different unfamiliar stimuli. We experimentally confirmed model predictions showing that trial-by-trial variability in neuronal activity indexes the landscape and predicts individual variation. These results show that neural stability is a critical component of the MFC neural dynamics that underpins individual variation in decision-making.

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Language(s): eng - English
 Dates: 2018-12
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: ISI: 000451324700014
DOI: 10.1038/s41593-018-0263-5
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Title: Nature Neuroscience
  Other : Nat. Neurosci.
Source Genre: Journal
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Publ. Info: New York, NY : Nature America Inc.
Pages: - Volume / Issue: 21 (12) Sequence Number: - Start / End Page: 1764 - 1773 Identifier: ISSN: 1097-6256
CoNE: https://pure.mpg.de/cone/journals/resource/954925610931