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  Paleomicrobiology: Diagnosis and Evolution of Ancient Pathogens

Bos, K. I., Kühnert, D., Herbig, A., Esquivel Gomez, L. R., Andrades Valtueña, A., Barquera Lozano, R. J., et al. (2019). Paleomicrobiology: Diagnosis and Evolution of Ancient Pathogens. Annual Review of Microbiology, 73(1), 29.1-29.28. doi:10.1146/annurev-micro-090817-062436.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-41AA-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-41AD-0
Genre: Journal Article

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 Creators:
Bos, Kirsten I.1, 2, Author              
Kühnert, Denise3, Author              
Herbig, Alexander2, Author              
Esquivel Gomez, Luis Roger3, Author              
Andrades Valtueña, Aida2, Author              
Barquera Lozano, Rodrigo José2, Author              
Giffin, Karen2, Author              
Lankapalli, Aditya Kumar2, Author              
Nelson, Elizabeth A.2, Author              
Sabin, Susanna2, Author              
Spyrou, Maria A.2, Author              
Krause, Johannes2, 4, Author              
Affiliations:
1CoDisEASe, Max Planck Institute for the Science of Human History, Max Planck Society, ou_3033585              
2Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2074310              
3tide, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2591691              
4MHAAM, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2541699              

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Free keywords: ancient DNA, pathogen evolution, disease emergence, molecular dating, paleopathology
 Abstract: The last century has witnessed progress in the study of ancient infectious disease from purely medical descriptions of past ailments to dynamic interpretations of past population health that draw upon multiple perspectives. The recent adoption of high-throughput DNA sequencing has led to an expanded understanding of pathogen presence, evolution, and ecology across the globe. This genomic revolution has led to the identification of disease-causing microbes in both expected and unexpected contexts, while also providing for the genomic characterization of ancient pathogens previously believed to be unattainable by available methods. In this review we explore the development of DNA-based ancient pathogen research, the specialized methods and tools that have emerged to authenticate and explore infectious disease of the past, and the unique challenges that persist in molecular paleopathology. We offer guidelines to mitigate the impact of these challenges, which will allow for more reliable interpretations of data in this rapidly evolving field of investigation. Expected final online publication date for the Annual Review of Microbiology Volume 73 is September 9, 2019. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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Language(s): eng - English
 Dates: 2019-09-092019-10-12
 Publication Status: Published in print
 Pages: 28
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1146/annurev-micro-090817-062436
Other: shh2289
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Title: Annual Review of Microbiology
Source Genre: Journal
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Publ. Info: Stanford, Calif. : Annual Reviews, Inc.
Pages: - Volume / Issue: 73 (1) Sequence Number: - Start / End Page: 29.1 - 29.28 Identifier: ISSN: 0066-4227
CoNE: https://pure.mpg.de/cone/journals/resource/954925458045