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  MEMRI Reveals Plasticity Changes in the Auditory Midbrains of Mice After Two-Tone Rearing

Yu, X., Sanes, D., Zou, J., Aristizábal, O., Zaim, Y., & Turnbull, D. (2007). MEMRI Reveals Plasticity Changes in the Auditory Midbrains of Mice After Two-Tone Rearing. In 2007 Joint Annual Meeting ISMRM-ESMRMB (pp. 480).

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 Creators:
Yu, X1, Author           
Sanes, DH, Author
Zou, J, Author
Aristizábal, O, Author
Zaim, YW, Author
Turnbull, DH, Author
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1External Organizations, ou_persistent22              

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 Abstract: We report that large-scale reorganization of
the mouse auditory midbrain tonotopic map is induced by a specific sound rearing e
nvironment consisting of
paired low and high frequency t
ones. Using a Manganese enhanced MRI (MEMRI) t
echnique with 100 micron resolution, we found that
two-tone rearing
prevented the appearance of separated frequency-specific respons
es; instead, a significant volume of the auditory midbrain beca
me responsive to both
rearing frequencies. Our study characteri
zed the developmental plasticity in the a
uditory midbrain, providing a critical workin
g model to study the experience dependent plasticity using MEMRI.

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 Dates: 2007-05
 Publication Status: Published online
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Title: 2007 Joint Annual Meeting ISMRM-ESMRMB
Place of Event: Berlin, Germany
Start-/End Date: 2007-05-19 - 2007-05-25

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Title: 2007 Joint Annual Meeting ISMRM-ESMRMB
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 2453 Start / End Page: 480 Identifier: -