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  Quantification of hydroxyl exchange of D‐Glucose at physiological conditions for optimization of glucoCEST MRI at 3, 7 and 9.4 Tesla

Zaiss, M., Anemone, A., Goerke, S., Longo, D., Herz, K., Pohmann, R., et al. (2019). Quantification of hydroxyl exchange of D‐Glucose at physiological conditions for optimization of glucoCEST MRI at 3, 7 and 9.4 Tesla. NMR in Biomedicine, 32(9), 1-14. doi:10.1002/nbm.4113.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-4BA1-2 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-7D45-3
Genre: Journal Article

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Zaiss, M1, 2, Author              
Anemone, A, Author
Goerke, S, Author
Longo, DL, Author
Herz, K1, 2, Author              
Pohmann, R1, 2, Author              
Aime, S, Author
Rivlin, M, Author
Navon, G, Author
Golay, X, Author
Scheffler, K1, 2, Author              
Affiliations:
1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: Aims To determine individual glucose hydroxyl exchange rates at physiological conditions and use this information for numerical optimization of glucoCEST/CESL preparation. To give guidelines for in vivo glucoCEST/CESL measurement parameters at clinical and ultra‐high field strengths. Methods Five glucose solution samples at different pH values were measured at 14.1 T at various B1 power levels. Multi‐B1‐Z‐spectra Bloch‐McConnell fits at physiological pH were further improved by the fitting of Z‐spectra of five pH values simultaneously. The obtained exchange rates were used in a six‐pool Bloch‐McConnell simulation including a tissue‐like water pool and semi‐solid MT pool with different CEST and CESL presaturation pulse trains. In vivo glucose injection experiments were performed in a tumor mouse model at 7 T. Results and discussion Glucose Z‐spectra could be fitted with four exchanging pools at 0.66, 1.28, 2.08 and 2.88 ppm. Corresponding hydroxyl exchange rates could be determined at pH = 7.2, T = 37°C and 1X PBS. Simulation of saturation transfer for this glucose system in a gray matter‐like and a tumor‐like system revealed optimal pulses at different field strengths of 9.4, 7 and 3 T. Different existing sequences and approaches are simulated and discussed. The optima found could be experimentally verified in an animal model at 7 T. Conclusion For the determined fast exchange regime, presaturation pulses in the spin‐lock regime (long recover time, short yet strong saturation) were found to be optimal. This study gives an estimation for optimization of the glucoCEST signal in vivo on the basis of glucose exchange rate at physiological conditions.

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 Dates: 2019-072019-09
 Publication Status: Published in print
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 Identifiers: DOI: 10.1002/nbm.4113
eDoc: e4113
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Title: NMR in Biomedicine
Source Genre: Journal
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Publ. Info: London : Heyden & Son
Pages: - Volume / Issue: 32 (9) Sequence Number: - Start / End Page: 1 - 14 Identifier: ISSN: 0952-3480
CoNE: https://pure.mpg.de/cone/journals/resource/954925574973