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  The dual lifestyle of genome‐integrating virophages in protists

Berjón‐Otero, M., Koslová, A., & Fischer, M. (2019). The dual lifestyle of genome‐integrating virophages in protists. Annals of the New York Academy of Sciences, 1447(1), 97-109. doi:10.1111/nyas.14118.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-4D29-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-4D2A-8
Genre: Journal Article

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AnnNYAS_1447_2019_97.pdf (Any fulltext), 2MB
 
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 Creators:
Berjón‐Otero, Mónica1, Author              
Koslová, Anna1, Author              
Fischer, Matthias1, Author              
Affiliations:
1Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research, Max Planck Society, ou_1497700              

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Free keywords: genome integration; host-parasite interaction; protist; virophage; virus
 Abstract: DNA viruses with efficient host genome integration capability were unknown in eukaryotes until recently. The discovery of virophages, satellite-like DNA viruses that depend on lytic giant viruses that infect protists, revealed a genetically diverse group of viruses with high genome mobility. Virophages can act as strong inhibitors of their associated giant viruses, and the resulting beneficial effects on their unicellular hosts resemble a population-based antiviral defense mechanism. By comparing various aspects of genome-integrating virophages, in particular the virophage mavirus, with other mobile genetic elements and parasite-derived defense mechanisms in eukaryotes and prokaryotes, we show that virophages share many features with other host-parasite systems. Yet, the dual lifestyle exhibited by mavirus remains unprecedented among eukaryotic DNA viruses, with potentially far-reaching ecological and evolutionary consequences for the host.

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Language(s): eng - English
 Dates: 2019-04-212019-04-152019-02-042019-07-152019-06-04
 Publication Status: Published in print
 Pages: 13
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
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Title: Annals of the New York Academy of Sciences
  Other : Ann. N.Y. Acad. Sci.
Source Genre: Journal
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Publ. Info: New York : New York Academy of Sciences
Pages: - Volume / Issue: 1447 (1) Sequence Number: - Start / End Page: 97 - 109 Identifier: ISSN: 0077-8923
CoNE: https://pure.mpg.de/cone/journals/resource/954926958894_2