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  Membrane-mimetic dendrimersomes engulf living bacteria via endocytosis

Kostina, N. Y., Rahimi, K., Xiao, Q., Haraszti, T., Dedisch, S., Spatz, J. P., et al. (2019). Membrane-mimetic dendrimersomes engulf living bacteria via endocytosis. Nano Letters, 19(8), 5732-5738. doi:10.1021/acs.nanolett.9b02349.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-4E58-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0005-87A3-A
Genre: Journal Article

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 Creators:
Kostina, Nina Yu., Author
Rahimi, Khosrow, Author
Xiao, Qi, Author
Haraszti, Tamás, Author
Dedisch, Sarah, Author
Spatz, Joachim P.1, 2, Author              
Schwaneberg, Ulrich, Author
Klein, Michael L., Author
Percec, Virgil, Author
Möller, Martin, Author
Rodriguez-Emmenegger, Cesar, Author
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              
2Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany, ou_persistent22              

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Free keywords: Janus dendrimer vesicles; Synthetic vesicles; artificial endocytosis of bacteria; cell membrane mimic; synthetic cells
 Abstract: There is much interest in developing vesicular microcompartments from natural and synthetic amphiphiles, enabling programmable interactions with living matter. Of particular interest is the development of vesicles capable of endocytosis of living bacteria. Despite the complexity of this process, theoretical studies predict that the endocytosis of prolate micro-objects is possible without the need of active cell machinery if the energy released upon bacterial adhesion to the membrane surpasses the energy required to bend the membrane. Nonetheless, natural liposomes and synthetic polymersomes fail to sufficiently recapitulate membrane properties to perform this advanced function. Here we report the engulfment of living bacteria into endosomes by cell-like dendrimersomes assembled from Janus dendrimers. Full engulfment occurred in less than a minute after contact. The process is driven by the adhesion of the bacterium to the dendrimersome's membrane by ultraweak interactions, comparable to those utilized by nature. The key to success relies on the combination of high flexibility and stability of the dendrimersomes. The key properties of the dendrimersomes are programmed into the molecular structures of their building blocks. The ability to support endocytosis highlights opportunities for the design and programming of dendrimersomes in biomedical research.

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Language(s): eng - English
 Dates: 2019-07-062019-06-102019-07-152019-07-15
 Publication Status: Published in print
 Pages: 7
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
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Title: Nano Letters
  Abbreviation : Nano Lett.
Source Genre: Journal
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Publ. Info: Washington, DC : American Chemical Society
Pages: - Volume / Issue: 19 (8) Sequence Number: - Start / End Page: 5732 - 5738 Identifier: ISSN: 1530-6984
CoNE: https://pure.mpg.de/cone/journals/resource/110978984570403