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  Associations between anxiety, body mass index, and sex hormones in women

Stanikova, D., Luck, T., Pabst, A., Bae, Y. J., Hinz, A., Glaesmer, H., et al. (2019). Associations between anxiety, body mass index, and sex hormones in women. Frontiers in Psychiatry, 10: 479. doi:10.3389/fpsyt.2019.00479.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-50B8-2 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-7038-F
Genre: Journal Article

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 Creators:
Stanikova, Daniela1, 2, 3, Author
Luck, Tobias4, 5, Author
Pabst, Alexander1, Author
Bae, Yoon Ju6, Author
Hinz, Andreas7, Author
Glaesmer, Heide7, Author
Stanik, Juraj2, 3, 8, Author
Sacher, Julia9, 10, 11, Author              
Engel, Christoph5, 12, Author
Enzenbach, Cornelia5, 12, Author
Wirkner, Kerstin5, Author
Ceglarek, Uta5, 6, Author
Thiery, Joachim5, 6, Author
Kratzsch, Juergen6, Author
Riedel-Heller, Steffi G.1, Author
Affiliations:
1Institute of Social Medicine, Occupational Health and Public Health (ISAP), University Hospital Leipzig, Germany, ou_persistent22              
2Biomedical Research Center, Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovakia, ou_persistent22              
3Department of Pediatrics, Medical Faculty, Comenius University, Bratislava, Slovakia, ou_persistent22              
4Department of Economic & Social Sciences, University of Applied Sciences Nordhausen, Germany, ou_persistent22              
5Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22              
6Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (ILM), University of Leipzig, Germany, ou_persistent22              
7Department of Medical Psychology and Medical Sociology, University of Leipzig, Germany, ou_persistent22              
8Center for Pediatric Research Leipzig (CPL), University Hospital Leipzig, Germany, ou_persistent22              
9Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
10EGG(Emotions & neuroimaGinG)-Lab, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_persistent22              
11Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
12Institute for Medical Informatics, Statistics and Epidemiology (IMISE), University of Leipzig, Germany, ou_persistent22              

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Free keywords: Anxiety; Body mass index; Obesity; Sex hormones; Testosterone; Estrogen; Women
 Abstract: Background: Several studies have shown a positive association between anxiety and obesity, particularly in women. We aimed to study whether sex hormone alterations related to obesity might play a role in this association. Patients and methods: Data for this study were obtained from a population-based cohort study (the LIFE-Adult-Study). A total of 3,124 adult women (970 premenopausal and 2,154 postmenopausal) were included into the analyses. The anxiety symptomatology was assessed using the GAD-7 questionnaire (cut-off ≥ 10 points). Sex hormones were measured from fasting serum samples. Results: We did not find significant differences in anxiety prevalence in premenopausal obese women compared with normal-weight controls (4.8% vs. 5.5%). Both obesity and anxiety symptomatology were separately associated with the same sex hormone alteration in premenopausal women: higher total testosterone level (0.97 ± 0.50 in obese vs. 0.86 ± 0.49 nmol/L in normal-weight women, p = 0.026 and 1.04 ± 0.59 in women with vs. 0.88 ± 0.49 nmol/L in women without anxiety symptomatology, p = 0.023). However, women with anxiety symptomatology had non-significantly higher estradiol levels than women without anxiety symptomatology (548.0 ± 507.6 vs. 426.2 ± 474.0 pmol/L), whereas obesity was associated with lower estradiol levels compared with those in normal-weight group (332.7 ± 386.5 vs. 470.8 ± 616.0 pmol/L). Women with anxiety symptomatology had also significantly higher testosterone and estradiol composition (p = 0.006). No associations of sex hormone levels and BMI with anxiety symptomatology in postmenopausal women were found. Conclusions: Although both obesity and anxiety symptomatology were separately associated with higher testosterone level, there was an opposite impact of anxiety and obesity on estradiol levels in premenopausal women. We did not find an evidence that the sex hormone alterations related to obesity are playing a significant role in anxiety symptomatology in premenopausal women. This could be the explanation why we did not find an association between obesity and anxiety. In postmenopausal women, other mechanisms seem to work than in the premenopausal group.

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Language(s): eng - English
 Dates: 2019-04-192019-06-182019-07-04
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.3389/fpsyt.2019.00479
PMID: 31333520
PMC: PMC6620895
Other: eCollection 2019
 Degree: -

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Project name : -
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Funding organization : LIFE – Leipzig Research Center for Civilization Diseases, University of Leipzig
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Funding organization : European Union (EU)
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Funding program : European Regional Development Fund
Funding organization : European Commission (EC)
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Funding organization : Free State of Saxony
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Funding program : European Social Fund
Funding organization : European Commission (EC)
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Grant ID : 01EO1501
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Funding organization : IFB Adiposity Diseases, German Federal Ministry of Education and Research (BMBF)
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Funding program : Research Fellowship
Funding organization : European Society for Pediatric Endocrinology (ESPE)
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Funding organization : German Research Foundation (DFG)
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Funding program : Open Access Publishing
Funding organization : University Leipzig

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Title: Frontiers in Psychiatry
  Abbreviation : Front Psychiatry
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Lausanne, Switzerland : Frontiers Research Foundation
Pages: - Volume / Issue: 10 Sequence Number: 479 Start / End Page: - Identifier: ISSN: 1664-0640
CoNE: https://pure.mpg.de/cone/journals/resource/16640640