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  High resolution atlas of the venous brain vasculature from 7 T quantitative susceptibility maps

Huck, J., Wanner, Y., Fan, A. P., Jäger, A.-T., Grahl, S., Schneider, U., et al. (2019). High resolution atlas of the venous brain vasculature from 7 T quantitative susceptibility maps. Brain Structure & Function. doi:10.1007/s00429-019-01919-4.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-5310-C Version Permalink: http://hdl.handle.net/21.11116/0000-0004-6449-A
Genre: Journal Article

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 Creators:
Huck, Julia1, Author
Wanner, Yvonne1, 2, Author
Fan, Audrey P.3, Author
Jäger, Anna-Thekla4, Author
Grahl, Sophia4, Author
Schneider, Uta4, Author
Villringer, Arno4, 5, 6, 7, Author              
Steele, Christopher4, 8, Author              
Tardif, Christine9, 10, Author              
Bazin, Pierre-Louis4, 11, Author              
Gauthier, Claudine1, 12, Author              
Affiliations:
1Department of Physics, Concordia University, Montréal, QC, Canada, ou_persistent22              
2Stuttgart University, Germany, ou_persistent22              
3Stanford University, CA, USA, ou_persistent22              
4Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
5Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
6Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              
7Collaborative Research Center Obesity Mechanisms, Institute of Biochemistry, University of Leipzig, Germany, ou_persistent22              
8Department of Psychology, Concordia University, Montréal, QC, Canada, ou_persistent22              
9Department of Biomedical Engineering, Douglas Mental Health University Institute, McGill University, Montréal, QC, Canada, ou_persistent22              
10Montreal Neurological Institute and Hospital, McGill University, Montréal, QC, Canada, ou_persistent22              
11Faculty of Social and Behavioural Science, Cognitive Science Center Amsterdam, University of Amsterdam, the Netherlands, ou_persistent22              
12Montreal Heart Institute, QC, Canada, ou_persistent22              

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Free keywords: Venous vasculature; QSM; UHF-MRI; Vein atlas; Vein segmentation; Cerebral vasculature
 Abstract: The vascular organization of the human brain can determine neurological and neurophysiological functions, yet thus far it has not been comprehensively mapped. Aging and diseases such as dementia are known to be associated with changes to the vasculature and normative data could help detect these vascular changes in neuroimaging studies. Furthermore, given the well-known impact of venous vessels on the blood oxygen level dependent (BOLD) signal, information about the common location of veins could help detect biases in existing datasets. In this work, a quantitative atlas of the venous vasculature using quantitative susceptibility maps (QSM) acquired with a 0.6-mm isotropic resolution is presented. The Venous Neuroanatomy (VENAT) atlas was created from 5 repeated 7 Tesla MRI measurements in young and healthy volunteers (n = 20, 10 females, mean age = 25.1 ± 2.5 years) using a two-step registration method on 3D segmentations of the venous vasculature. This cerebral vein atlas includes the average vessel location, diameter (mean: 0.84 ± 0.33 mm) and curvature (0.11 ± 0.05 mm−1) from all participants and provides an in vivo measure of the angio-architectonic organization of the human brain and its variability. This atlas can be used as a basis to understand changes in the vasculature during aging and neurodegeneration, as well as vascular and physiological effects in neuroimaging.

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Language(s): eng - English
 Dates: 2018-11-192019-06-262019-07-05
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1007/s00429-019-01919-4
Other: Epub ahead of print
PMID: 31278570
 Degree: -

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Project name : -
Grant ID : -
Funding program : -
Funding organization : Max Planck Society
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Grant ID : RGPIN-2015-04665
Funding program : -
Funding organization : Canadian National Sciences and Engineering Research Council
Project name : -
Grant ID : -
Funding program : -
Funding organization : Heart and Stroke Foundation of Canada
Project name : -
Grant ID : 1K99NS102884
Funding program : -
Funding organization : National Institute of Health
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Grant ID : -
Funding program : -
Funding organization : Quebec Bio-Imaging Network (QBIN)

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Title: Brain Structure & Function
  Abbreviation : Brain Struct Funct
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Berlin : Springer
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 1863-2653
CoNE: https://pure.mpg.de/cone/journals/resource/1863-2653