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  Genetic diversity of HLA system in two populations from Querétaro, Mexico: Querétaro city and rural Querétaro

Martínez-Álvarez, J. C., Barquera Lozano, R. J., Hernández-Zaragoza, D. I., Bravo-Acevedo, A., Clayton, S., Arrieta-Bolaños, E., et al. (2019). Genetic diversity of HLA system in two populations from Querétaro, Mexico: Querétaro city and rural Querétaro. Human Immunology. doi:10.1016/j.humimm.2019.07.296.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-57E3-A Version Permalink: http://hdl.handle.net/21.11116/0000-0004-5B72-6
Genre: Journal Article

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 Creators:
Martínez-Álvarez, Julio César, Author
Barquera Lozano, Rodrigo José1, Author              
Hernández-Zaragoza, Diana Iraíz, Author
Bravo-Acevedo, Alicia, Author
Clayton, Stephen, Author
Arrieta-Bolaños, Esteban, Author
Immel, Alexander1, Author              
Benítez-Arvizu, Gamaliel, Author
Arrazola-García, María Araceli, Author
Juárez-Barreto, Vicencio, Author
Vega-Martínez, María del Rosario, Author
Juárez-Nicolás, Francisco, Author
Escutia-González, Ariadna Berenice, Author
Martínez-Bezies, Virginia, Author
García-Álvarez, Raquel, Author
Salgado-Galicia, Norma, Author
Zúñiga, Joaquín, Author
Yunis, Edmond J., Author
Bekker-Méndez, Carolina, Author
Granados, Julio, Author
Affiliations:
1Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2074310              

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Free keywords: HLA, Immunogenetics, Population genetics, Querétaro, Admixture
 Abstract: We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 88 Mexicans from the state of Querétaro living in the city of Querétaro (N = 45) and rural communities (N = 43), to obtain information regarding allelic and haplotypic frequencies. We find that the most frequent haplotypes in the state of Querétaro include seven Native American, two European and one Asian haplotype. Admixture estimates revealed that the main genetic components in the state of Querétaro are Native American (51.82 ± 4.42 by ML; 42.61 of Native American haplotypes) and European (48.18 ± 3.55 by ML; 46.02 of European haplotypes), with a virtually absent African genetic component (0.00 ± 4.25 by ML; 4.55 of African haplotypes).

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Language(s): eng - English
 Dates: 2019-07-25
 Publication Status: Published online
 Pages: 3
 Publishing info: -
 Table of Contents: -
 Rev. Method: Internal
 Identifiers: DOI: 10.1016/j.humimm.2019.07.296
Other: shh2300
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Title: Human Immunology
Source Genre: Journal
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Publ. Info: New York, N.Y. : Elsevier
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 0198-8859
CoNE: https://pure.mpg.de/cone/journals/resource/954925492912