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  Genetic diversity of HLA system in two populations from San Luis Potosí, Mexico: San Luis Potosí City and rural San Luis Potosí

Hernández-Zaragoza, D. I., Rodríguez-Munguía, T. J., Barquera, R., Adalid-Sáinz, C., Arrieta-Bolaños, E., Clayton, S., et al. (2019). Genetic diversity of HLA system in two populations from San Luis Potosí, Mexico: San Luis Potosí City and rural San Luis Potosí. Human Immunology. doi:10.1016/j.humimm.2019.07.291.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-57EA-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-5B71-7
Genre: Journal Article

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 Creators:
Hernández-Zaragoza, Diana Iraíz, Author
Rodríguez-Munguía, Tirzo Jesús, Author
Barquera, Rodrigo1, Author              
Adalid-Sáinz, Carmen, Author
Arrieta-Bolaños, Esteban, Author
Clayton, Stephen1, Author              
Pacheco-Ubaldo, Hanna, Author
González-Medina, Liliana, Author
Lona-Sánchez, Abraham, Author
Bravo-Acevedo, Alicia, Author
Aquino-Rubio, Guadalupe, Author
González-Martínez, Marisela del Rocío, Author
Delgado-Aguirre, Héctor, Author
Escareño-Montiel, Néstor, Author
Jaramillo-Rodríguez, Yolanda, Author
Salgado-Adame, Antonio, Author
la Cruz, Federico Juárez-de, Author
Zúñiga, Joaquín, Author
Yunis, Edmond J., Author
Bekker-Méndez, Carolina, Author
Granados, Julio, Author more..
Affiliations:
1Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2074310              

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Free keywords: HLA, Immunogenetics, Population genetics, San Luis Potosí, Admixture
 Abstract: We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 117 Mexicans from the state of San Luis Potosí living in the city of San Luis Potosí (N = 30) and rural communities (N = 87), to obtain information regarding allelic and haplotypic frequencies. We find that the most frequent haplotypes in the state include 13 Native American, six European, two African and two Asian haplotypes. Admixture estimates revealed that the main genetic components are Native American (52.72 ± 0.66 by ML; 48.29 of Native American haplotypes) and European (34.62 ± 4.28 by ML; 32.48 of European haplotypes), and a relatively high African genetic component (12.66 ± 4.61 by ML; 10.26 of African haplotypes).

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Language(s): eng - English
 Dates: 2019-07-24
 Publication Status: Published online
 Pages: 3
 Publishing info: -
 Table of Contents: -
 Rev. Method: Internal
 Identifiers: DOI: 10.1016/j.humimm.2019.07.291
Other: shh2301
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Title: Human Immunology
Source Genre: Journal
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Publ. Info: New York, N.Y. : Elsevier
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 0198-8859
CoNE: https://pure.mpg.de/cone/journals/resource/954925492912