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  Genetic diversity of HLA system in two populations from Morelos, Mexico: Cuernavaca and rural Morelos

Ortega-Yáñez, A., Barquera, R., Curiel-Giles, L., Martínez-Álvarez, J. C., Macías-Medrano, R. M., Arrieta-Bolaños, E., et al. (2019). Genetic diversity of HLA system in two populations from Morelos, Mexico: Cuernavaca and rural Morelos. Human Immunology. doi:10.1016/j.humimm.2019.07.289.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-57FF-C Version Permalink: http://hdl.handle.net/21.11116/0000-0005-842D-4
Genre: Journal Article

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 Creators:
Ortega-Yáñez, Andrea, Author
Barquera, Rodrigo1, Author              
Curiel-Giles, Laura, Author
Martínez-Álvarez, Julio César, Author
Macías-Medrano, Rosa María, Author
Arrieta-Bolaños, Esteban, Author
Clayton, Stephen1, Author              
Bravo-Acevedo, Alicia, Author
Hernández-Zaragoza, Diana Iraíz, Author
Immel, Alexander1, Author              
Vega-Martínez, María del Rosario, Author
Benítez-Arvizu, Gamaliel, Author
Arrazola-García, María Araceli, Author
Arriaga-Perea, Agustín Jericó, Author
Juárez-Cortés, Eva Dolores, Author
Juárez-Barreto, Vicencio, Author
Salgado-Galicia, Norma, Author
Novelo-Garza, Bárbara, Author
Zúñiga, Joaquín, Author
Yunis, Edmond J., Author
Bekker-Méndez, Carolina, AuthorGranados, Julio, Author more..
Affiliations:
1Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2074310              

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Free keywords: HLA, Immunogenetics, Population genetics, Morelos, Admixture
 Abstract: We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 112 Mexicans from the state of Morelos living in the city of Cuernavaca (N = 82) and rural communities (N = 30), to obtain information regarding allelic and haplotypic frequencies. The most frequent haplotypes in Morelos include seven Native American, one European, one African and one Asian haplotype. Admixture estimates revealed that the main genetic components in Morelos are Native American (60.43 ± 2.22 by ML; 53.57 of Native American haplotypes) and European (39.58 ± 3.70 by ML; 27.68 of European haplotypes), and a virtually absent African genetic component (0.00 ± 4.93 by ML; but 11.16 of African haplotypes).

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Language(s): eng - English
 Dates: 2019-07-22
 Publication Status: Published online
 Pages: 3
 Publishing info: -
 Table of Contents: -
 Rev. Method: Internal
 Identifiers: DOI: 10.1016/j.humimm.2019.07.289
Other: shh2302
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Title: Human Immunology
Source Genre: Journal
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Publ. Info: New York, N.Y. : Elsevier
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 0198-8859
CoNE: https://pure.mpg.de/cone/journals/resource/954925492912