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  Neuroplasticity of language in left‐hemisphere stroke: Evidence linking subsecond electrophysiology and structural connections

Piai, V., Meyer, L., Dronkers, N., & Robert T., K. (2017). Neuroplasticity of language in left‐hemisphere stroke: Evidence linking subsecond electrophysiology and structural connections. Human Brain Mapping, 38(6), 3151-3162. doi:10.1002/hbm.23581.

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Piai_2017.pdf (Preprint), 829KB
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https://onlinelibrary.wiley.com/doi/10.1002/hbm.23581 (Verlagsversion)
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 Urheber:
Piai, Vitória 1, 2, 3, 4, Autor
Meyer, Lars5, Autor                 
Dronkers, Nina4, 6, 7, Autor
Robert T., Knight3, Autor
Affiliations:
1Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands, ou_persistent22              
2Department of Medical Psychology, Radboud University Medical Center, Nijmegen, the Netherlands, ou_persistent22              
3Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA, ou_persistent22              
4Center for Aphasia and Related Disorders, Veterans Affairs Northern California Health Care System, Martinez, CA, USA, ou_persistent22              
5Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634551              
6Department of Neurology, University of California Davis, CA, USA, ou_persistent22              
7Neurolinguistics Laboratory, National Research University Higher School of Economics, Moscow, Russia, ou_persistent22              

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Schlagwörter: Context; Disconnection; Neuroplasticity; Oscillations; Production; Splenium; Tapetum
 Zusammenfassung: The understanding of neuroplasticity following stroke is predominantly based on neuroimaging measures that cannot address the subsecond neurodynamics of impaired language processing. We combined behavioral and electrophysiological measures and structural‐connectivity estimates to characterize neuroplasticity underlying successful compensation of language abilities after left‐hemispheric stroke. We recorded the electroencephalogram from patients with stroke lesions to the left temporal lobe and from matched controls during context‐driven word retrieval. Participants heard lead‐in sentences that either constrained the final word (“He locked the door with the”) or not (“She walked in here with the”). The last word was shown as a picture to be named. Individual‐participant analyses were conducted, focusing on oscillatory power as a subsecond indicator of a brain region's functional neurophysiological computations. All participants named pictures faster following constrained than unconstrained sentences, except for two patients, who had extensive damage to the left temporal lobe. Left‐lateralized alpha–beta oscillatory power decreased in controls pre‐picture presentation for constrained relative to unconstrained contexts. In patients, the alpha–beta power decreases were observed with the same time course as in controls but were lateralized to the intact right hemisphere. The right lateralization depended on the probability of white‐matter connections between the bilateral temporal lobes. The two patients who performed poorly behaviorally showed no alpha–beta power decreases. Our findings suggest that incorporating direct measures of neural activity into investigations of neuroplasticity can provide important neural markers to help predict language recovery, assess the progress of neurorehabilitation, and delineate targets for therapeutic neuromodulation.

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Sprache(n): eng - English
 Datum: 2017-03-082016-11-152017-03-112017-03-272017-06
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1002/hbm.23581
PMID: 28345282
PMC: PMC5610921
Anderer: Epub 2017
 Art des Abschluß: -

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Projektname : -
Grant ID : 446‐13‐009
Förderprogramm : -
Förderorganisation : Netherlands Organization for Scientific Research (NWO)
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Grant ID : NINDS R37 NS21135
Förderprogramm : -
Förderorganisation : National Institutes of Health (NIH)
Projektname : -
Grant ID : CX000254
Förderprogramm : -
Förderorganisation : US Department of Veterans Affairs Clinical Sciences Research and Development
Projektname : -
Grant ID : -
Förderprogramm : Basic Research Program
Förderorganisation : National Research University Higher School of Economics
Projektname : -
Grant ID : -
Förderprogramm : Russian Academic Excellence Project 5–100
Förderorganisation : Ministry of Science and Higher Education of the Russian Federation

Quelle 1

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Titel: Human Brain Mapping
Genre der Quelle: Zeitschrift
 Urheber:
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Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 38 (6) Artikelnummer: - Start- / Endseite: 3151 - 3162 Identifikator: ISSN: 1065-9471
CoNE: https://pure.mpg.de/cone/journals/resource/954925601686