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  Genetic diversity of HLA system in two populations from Yucatán, Mexico: Mérida and rural Yucatán

Lara-Riegos, J., Barquera, R., Castillo-Chávez, O. d., Medina-Escobedo, C. E., Hernández-Zaragoza, D. I., Arrieta-Bolaños, E., et al. (2020). Genetic diversity of HLA system in two populations from Yucatán, Mexico: Mérida and rural Yucatán. Human Immunology, 81(9), 569-572. doi:10.1016/j.humimm.2019.07.280.

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Lara-Riegos, Julio, Author
Barquera, Rodrigo1, Author              
Castillo-Chávez, Oana del, Author
Medina-Escobedo, Carolina Elizabeth, Author
Hernández-Zaragoza, Diana Iraíz, Author
Arrieta-Bolaños, Esteban, Author
Clayton, Stephen1, Author              
Ponnandai-Shanmugavel, Komathi Sree, Author
Bravo-Acevedo, Alicia, Author
Zúñiga, Joaquín, Author
Yunis, Edmond J., Author
Bekker-Méndez, Carolina, Author
Granados, Julio, Author
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1Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2074310              

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Free keywords: HLA, Immunogenetics, Population genetics, Yucatán, Admixture
 Abstract: We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 324 Mexicans from the state of Yucatán living in the city of Mérida (N = 192) and rural communities (N = 132), to obtain information regarding allelic and haplotypic frequencies. We found that the most frequent haplotypes in the state of Yucatán include 16 Native American and one European haplotype. Admixture estimates revealed that the main genetic components in Yucatán are Native American (81.54 ± 4.99% by ML; 62.92% of Native American haplotypes) and European (11.50 ± 15.43% by ML; 23.26% of European haplotypes), and a less prominent African genetic component (6.96 ± 10.47% by ML; 5.93% of African haplotypes).

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Language(s): eng - English
 Dates: 2019-07-222020-09
 Publication Status: Published in print
 Pages: 4
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.humimm.2019.07.280
Other: shh2304
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Title: Human Immunology
Source Genre: Journal
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Publ. Info: New York, N.Y. : Elsevier
Pages: - Volume / Issue: 81 (9) Sequence Number: - Start / End Page: 569 - 572 Identifier: ISSN: 0198-8859
CoNE: https://pure.mpg.de/cone/journals/resource/954925492912