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  Hyperpolarization of amino acids in water utilizing parahydrogen on a rhodium nanocatalyst.

Kaltschnee, L., Jagtap, A., McCormick, J., Wagner, S., Bouchard, L. S., Utz, M., et al. (2019). Hyperpolarization of amino acids in water utilizing parahydrogen on a rhodium nanocatalyst. Chemistry - A European Journal, 25(47), 11031-11035. doi:10.1002/chem.201902878.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-5839-A Version Permalink: http://hdl.handle.net/21.11116/0000-0004-9609-9
Genre: Journal Article

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 Creators:
Kaltschnee, L.1, Author              
Jagtap, A.1, Author              
McCormick, J., Author
Wagner, S., Author
Bouchard, L. S., Author
Utz, M., Author
Griesinger, C.2, Author              
Glöggler, S.1, Author              
Affiliations:
1Research Group of NMR Signal Enhancement, MPI for Biophysical Chemistry, Max Planck Society, ou_2396691              
2Department of NMR Based Structural Biology, MPI for biophysical chemistry, Max Planck Society, ou_578567              

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Free keywords: NMR spectroscopy; PHIP; amino acids; hyperpolarization; nanoparticles
 Abstract: NMR offers many possibilities in chemical analysis, structural investigations, and medical diagnostics. Although it is broadly used, one of NMR spectroscopies main drawbacks is low sensitivity. Hyperpolarization techniques enhance NMR signals by more than four orders of magnitude allowing the design of new contrast agents. Parahydrogen induced polarization that utilizes the para-hydrogen's singlet state to create enhanced signals is of particular interest since it allows to produce molecular imaging agents within seconds. Herein, we present a strategy for signal enhancement of the carbonyl 13 C in amino acids by using parahydrogen, as demonstrated for glycine and alanine. Importantly, the hyperpolarization step is carried out in water and chemically unmodified canonical amino acids are obtained. Our approach thus offers a high degree of biocompatibility, which is crucial for further application. The rapid sample hyperpolarization (within seconds) may enable the continuous production of biologically useful probes, such as metabolic contrast agents or probes for structural biology.

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Language(s): eng - English
 Dates: 2019-06-252019-08-22
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1002/chem.201902878
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Title: Chemistry - A European Journal
Source Genre: Journal
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Pages: - Volume / Issue: 25 (47) Sequence Number: - Start / End Page: 11031 - 11035 Identifier: -