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  Genetic diversity of HLA system in two populations from Puebla, Mexico: Puebla city and rural Puebla

Gil, C. L., Barquera, R., de Pavón-Vargas, M. l. Á., la Cruz, F.-d.-R.-R.-d., Méndez-Mani, P., Arrieta-Bolaños, E., et al. (2019). Genetic diversity of HLA system in two populations from Puebla, Mexico: Puebla city and rural Puebla. Human Immunology. doi:10.1016/j.humimm.2019.07.290.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-583E-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-9902-D
Genre: Journal Article

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 Creators:
Gil, Concepción López, Author
Barquera, Rodrigo1, Author              
de Pavón-Vargas, María los Ángeles, Author
la Cruz, Flor del Rocío Ramos-de, Author
Méndez-Mani, Patricia, Author
Arrieta-Bolaños, Esteban, Author
Clayton, Stephen1, Author              
Hernández-Zaragoza, Diana Iraíz, Author
Bravo-Acevedo, Alicia, Author
Zúñiga, Joaquín, Author
Yunis, Edmond J., Author
Bekker-Méndez, Carolina, Author
Granados, Julio, Author
Affiliations:
1Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2074310              

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Free keywords: HLA, Immunogenetics, Population genetics, Puebla, Admixture
 Abstract: We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 2827 Mexicans from the state of Puebla living in the city of Puebla (N = 1994) and rural communities (N = 833), to obtain information regarding allelic and haplotypic frequencies. We found that the 16 most frequent haplotypes in Puebla are all of them Native American. Admixture estimates revealed that the main genetic components in the state of Puebla are Native American (72.21 ± 1.25 by ML; 63.30 of Native American haplotypes) and European (21.05 ± 1.92 by ML; 23.86 of European haplotypes), and a less prominent African genetic component (6.74 ± 2.20 by ML; 6.20 of African haplotypes).

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Language(s): eng - English
 Dates: 2019-07-22
 Publication Status: Published online
 Pages: 3
 Publishing info: -
 Table of Contents: -
 Rev. Method: Internal
 Identifiers: DOI: 10.1016/j.humimm.2019.07.290
Other: shh2305
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Title: Human Immunology
Source Genre: Journal
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Publ. Info: New York, N.Y. : Elsevier
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 0198-8859
CoNE: https://pure.mpg.de/cone/journals/resource/954925492912