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  Genetic diversity of HLA system in two populations from Hidalgo, Mexico: Pachuca and rural Hidalgo

Barquera, R., Martínez-Álvarez, J. C., Trejo-Ordoz, A. V., de Pavón-Vargas, M. l. Á., Vega-Martínez, M. d. R., Arrieta-Bolaños, E., et al. (2019). Genetic diversity of HLA system in two populations from Hidalgo, Mexico: Pachuca and rural Hidalgo. Human Immunology. doi:10.1016/j.humimm.2019.07.293.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-58B3-F Version Permalink: http://hdl.handle.net/21.11116/0000-0004-58B4-E
Genre: Journal Article

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 Creators:
Barquera, Rodrigo1, Author              
Martínez-Álvarez, Julio César, Author
Trejo-Ordoz, Alondra Victoria, Author
de Pavón-Vargas, María los Ángeles, Author
Vega-Martínez, María del Rosario, Author
Arrieta-Bolaños, Esteban, Author
Clayton, Stephen1, Author              
Ortega-Yáñez, Andrea, Author
Juárez-Cortés, Eva Dolores, Author
Juárez-Nicolás, Francisco, Author
López-Gil, Concepción, Author
Immel, Alexander1, Author              
Arrazola-García, María Araceli, Author
Juárez-Barreto, Vicencio, Author
Benítez-Arvizu, Gamaliel, Author
Arriaga-Perea, Agustín Jericó, Author
Martínez-Bezies, Virginia, Author
Macías-Medrano, Rosa María, Author
la Cruz, Flor del Rocío Ramos-de, Author
Hernández-Zaragoza, Diana Iraíz, Author
Bravo-Acevedo, Alicia, AuthorMéndez-Mani, Patricia, AuthorEscutia-González, Ariadna Berenice, AuthorMontiel-Hernández, Gustavo Daniel, AuthorGarcía-Álvarez, Raquel, AuthorSalgado-Galicia, Norma, AuthorNovelo-Garza, Bárbara, AuthorZúñiga, Joaquín, AuthorYunis, Edmond J., AuthorBekker-Méndez, Carolina, AuthorGranados, Julio, Author more..
Affiliations:
1Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2074310              

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Free keywords: HLA, Immunogenetics, Population genetics, Hidalgo, Admixture
 Abstract: We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 122 Mexicans from the state of Hidalgo living in the city of Pachuca (N = 41) and rural communities (N = 81), to obtain information regarding allelic and haplotypic frequencies. We find that the most frequent haplotypes in Hidalgo include eight Native American and one European haplotypes. Admixture estimates revealed that the main genetic components in Hidalgo are Native American (58.93 ± 2.16 by ML; 54.51 of Native American haplotypes) and European (32.49 ± 2.88 by ML; 28.69 of European haplotypes), and a relatively high African genetic component (8.58 ± 0.93 by ML; 6.97 of African haplotypes).

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Language(s): eng - English
 Dates: 2019-07-22
 Publication Status: Published online
 Pages: 4
 Publishing info: -
 Table of Contents: -
 Rev. Method: Internal
 Identifiers: DOI: 10.1016/j.humimm.2019.07.293
Other: shh2306
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Title: Human Immunology
Source Genre: Journal
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Publ. Info: New York, N.Y. : Elsevier
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 0198-8859
CoNE: https://pure.mpg.de/cone/journals/resource/954925492912