English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Functional Modules of the Proteostasis Network

Jayaraj, G. G., Hipp, M. S., & Hartl, F. U. (2019). Functional Modules of the Proteostasis Network. Cold Spring Harbor Perspectives in Biology. doi:10.1101/cshperspect.a033951.

Item is

Basic

show hide
Genre: Journal Article

Files

show Files
hide Files
:
Jayaraj et al submitted file.pdf (Preprint), 2MB
Name:
Jayaraj et al submitted file.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Jayaraj, Gopal G.1, Author              
Hipp, Mark S.1, Author              
Hartl, F. Ulrich1, Author              
Affiliations:
1Hartl, Franz-Ulrich / Cellular Biochemistry, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565152              

Content

show
hide
Free keywords: -
 Abstract: Cells invest in an extensive network of factors to maintain protein homeostasis (proteostasis) and prevent the accumulation of potentially toxic protein aggregates. This proteostasis network (PN) comprises the machineries for the biogenesis, folding, conformational maintenance, and degradation of proteins with molecular chaperones as central coordinators. Here, we review recent progress in understanding the modular architecture of the PN in mammalian cells and how it is modified during cell differentiation. We discuss the capacity and limitations of the PN in maintaining proteome integrity in the face of proteotoxic stresses, such as aggregate formation in neurodegenerative diseases. Finally, we outline various pharmacological interventions to ameliorate proteostasis imbalance.

Details

show
hide
Language(s):
 Dates: 2019
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1101/cshperspect.a033951
 Degree: -

Event

show

Legal Case

show

Project information

show hide
Project name : GA ERC‐2012‐SyG_318987–ToPAG
Grant ID : 318987
Funding program : Funding Programme 7 (FP7)
Funding organization : European Commission (EC)

Source 1

show
hide
Title: Cold Spring Harbor Perspectives in Biology
  Abbreviation : Cold Spring Harb Perspect Biol
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Cold Spring Harbor, NY : Cold Spring Harbor Laboratory Press
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 1943-0264
CoNE: https://pure.mpg.de/cone/journals/resource/1943-0264